Searchable abstracts of presentations at key conferences in endocrinology

ea0011oc60 | ThyroidOC57 British Thyroid Association Award | ECE2006

4-methylbenzylidene-camphor (4MBC) causes pituitary effects comparable to hypothyroidism

Hamann IH , Schmutzler C , Kirschmeyer P , Jarry H , Köhrle J

4-methylbenzylidene-camphor (4MBC) is an endocrine active compound used as an UV absorber in sunscreens and other cosmetics such as anti-aging lotions and day care products. 4MBC shows weak estrogenic effects on the reproductive system but strong anti-osteoporotic effects after chronic application (Seidlova-Wuttke D et al. 2005 Toxicol Appl Pharmacol. 24:in press). Additionally, 4MBC can be resorbed through the skin (Janjua NR et al. 2004 J Invest Dermatol...

ea0011p429 | Endocrine disruptors | ECE2006

The UV filter benzophenone 2 inactivates human recombinant thyroperoxidase in vitro and disturbs thyroid hormone homeostasis in rats

Schmutzler C , Bacinski A , Ambrugger P , Klammer H , Wuttke W , Grüters A , Jarry H , Köhrle J

UV filters are produced in high amounts for multiple uses. Their main application is in sun lotions for skin protection against accelerated ageing or cancer, but they are also found in many other cosmetics or in plastic materials to prevent their radiation-induced damage. Regardless of these protective properties, UV filters seem to interfere with both the reproductive and the thyroid endocrine axis. We here screened for effects of the UV filter benzophenone 2 (BP2) on thyroid...