Searchable abstracts of presentations at key conferences in endocrinology

ea0025p173 | Endocrine tumours and neoplasia | SFEBES2011

Adenosine receptors modulate chromogranin A secretion and growth of neuroendocrine tumours: potential targets for therapy

Kalhan Atul , Garibi Borzo , Jasani Bharat , Kidd Mark , Modlin Irvin , Pfragner Roswitha , Rees Aled , Ham Jack

Introduction: Neuroendocrine tumors of GI tract are a heterogeneous group of rare neoplasms that secrete peptides and amines. These tumors are highly vascular and their vascularity reflects increased tumour related angiogenesis. Adenosine, a major regulator of angiogenesis, is released by enhanced degradation of ATP, during cellular stress, damage and hypoxia.Material and methods: The expression of adenosine receptors (AR) was investigated in two human n...