Searchable abstracts of presentations at key conferences in endocrinology

ea0077p104 | Reproductive Endocrinology | SFEBES2021

An exploration of the association between CAG repeat status and mortality in men

Heald Adrian , Cook Michael , Javed Ahmed , Fachim Helene , O’Neill Terence , Wu Fred

Introduction: The androgen receptor (AR) mediates the peripheral effects of testosterone. The main mechanism of action for the AR is direct regulation of gene transcription. Available evidence suggests that the number of CAG repeats in exon-1 of the AR gene is negatively correlated with transcriptional activity of the AR and that CAG repeat number links to mortality rate in T2DM men. The aim of this analysis was to determine the association between CAG repeat number and all ca...