Searchable abstracts of presentations at key conferences in endocrinology

ea0022p739 | Steroid metabolism & action | ECE2010

Synthesis of 1,25-dihydroxyvitamin D in human bladder epithelial cells and vitamin D mediated cathelicidin induction

Bennett Jeanette , Zehnder Daniel , Jefferson Kieran , Bland Rosemary

It is now recognized that vitamin D influences the innate immune system and recent studies have highlighted the importance of local synthesis of 1,25-dihydroxyvitamin D (1,25D) for these responses. Production of 1,25D from 25-hydroxvitamin D (25D) is catalyzed by 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1; 1α-OHase). Vitamin D is metabolized by 24-hydroxylase (CYP24A1; 24-OHase). A key part of the innate immune response is pathogen recognition by the toll-like recep...

ea0044p129 | Neoplasia, cancer and late effects | SFEBES2016

Low vitamin D is associated with increased bladder cancer risk; a systematic review and evidence of a potential mechanism

Bland Rosemary , Chivu Corina , Jefferson Kieran , MacDonald Donald , Iqbal Gulnaz , Dunn Janet

Vitamin D deficiency is associated with the development of some cancers and in vitro 1,25-dihydroxyvitamin D (1,25D) reduces cell proliferation. We suggest that modification of tissue specific immune responses, as a consequence of local synthesis of 1,25D, may be key. To assess the impact of serum 25D on the risk of bladder cancer we conducted a systematic review. To test our hypothesis, expression of vitamin D signalling components and the synthesis of 1,25D were exa...