Searchable abstracts of presentations at key conferences in endocrinology

ea0044p45 | Bone and Calcium | SFEBES2016

Immunomodulation by vitamin D is associated with regulation of microRNAs

Li Danyang , Jeffery Louisa E. , Raza Karim , Hewison Martin

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), acting via the vitamin D receptor (VDR) is a potent regulator of gene expression, with effects on skeletal and extra-skeletal physiology. We have shown that actions of 1,25D on bone-forming osteoblasts also involve regulation of microRNAs (miRNAs) that play a key role in the functional development of these cells. In the current study, we have investigated miRNAs as mediators of innate and adaptive immune responses ...