Searchable abstracts of presentations at key conferences in endocrinology

ea0063p425 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Insulinoma: a case series of a tertiary care center

Jemel Manel , Jemel Manel , Kandara Hajer , Adel Meriem , El Guich Dorra , Jemni Houda , Kammoun Ines

Introduction: Insulinoma is rare tumor with an incidence of 1 in 250,000 patient-years. It presents with repeated episodes of hypoglycemia due to endogenous hyperinsulinemia, which occurs mostly in the fasting state. Insulinomas are usually sporadic, solitary, benign and encapsulated small lesions and majority of them measure <2 cm in diameter. They pose a challenge for pre-operative localization.Materials and methods: A retrospective study of patien...

ea0063p531 | Diabetes, Obesity and Metabolism 2 | ECE2019

TRMA syndrome (thiamine-responsive megaloblastic anemia): a case report

Jemel Manel , Jemel Manel , Jemaa Maroua Ben , Kandara Hajer , Jemni Houda , Kammoun Ines

Introduction: Thiamine responsive megaloblastic anemia (TRMA) syndrome, also known Rogers syndrome is a rare autosomal recessive inherited disorder characterized by a triad features of megaloblastic anemia, sensorineural deafness and diabetes mellitus. TRMA manifestation is caused by mutations in the gene SLC19A2 encoding a high-affinity thiamine transporter, which disturbs the active thiamine uptake into cells.Case Presentation...

ea0056p994 | Clinical case reports - Thyroid/Others | ECE2018

Pericarditis: uncommon onset of anti-neutrophil cytoplasmic antibody-associated vasculitis induced by methimazol

Jemel Manel , Sayadi Hanene , Khochtali Ines

Introduction: Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis drugs induced are a rare side effect of antithyroid drugs. It is more commonly associated with propylthiouracil (PTU). The clinical manifestations are polymorphic like in primary vasculitides, but less severe; ranging from less specifics syndromes to multiple organs injured and lifethreatening in rare case. Cardiac involvement is uncommon. Herby we present the first case report of a 25-yr-old wom...

ea0056ep118 | Pituitary and Neuroendocrinology | ECE2018

Antiphospholipid syndrome and pituitary necrosis

Jemel Manel , Sayadi Hanene , Khochtali Ines

Introduction: Antiphospholipid syndrome (APS) is an acquired thrombotic disorder. It mainly occurs with systemic disease or as a primary disorder. All organs may be involved by thrombosis. But endocrine disorders seen in antiphospholipid syndrome are rare. In the literature, rare cases of hypopituitarism with APS have been reported.The observation: It is a 27 years old patient who consults for headache with diplopia. The interview underlines galactorrhea...

ea0070ep331 | Pituitary and Neuroendocrinology | ECE2020

GH deficiency in children with sickle cell anemia: About a case

Dorraelguiche Dorra , Jemel Manel , Anis Grassa , Kandara Hajer , Kammoun Ines

Introduction: Growth retardation in sickle cell children is common and multifactorial. Recent evidence suggests damage to the somatotropic axis. We report the case of a patient followed for homozygous sickle cell anemia and in whom we discover an associated GH deficiency.Observation: It is a 13 year old child followed for homozygous sickle cell anemia, splenectomized for 2 years, not polytransfused. We were sent to the hematology department before a dela...

ea0070ep333 | Pituitary and Neuroendocrinology | ECE2020

Pituitary metastasis from lung cancer: uncomon presentation

Anis Grassa , Jemel Manel , Salma Salhi , Kandara Hajer , Kammoun Ines

Background: Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as anterior pituitary deficiency. Although pituitary gland metastasis is rare, it is underestimated, as it is commonly misdiagnosed with pituitary gland adenoma due to the lack of clear r...

ea0081ep340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

COVID-19 pandemic: Impact on follow up care of insulin-requiring diabetic patients

Kardi Asma , Gharbi Radhouen , Salem Maram Ben , Jemel Manel , Kandara Hajer , Chiboub Marwa , Kammoun Ines

Introduction: COVID-19 is a novel pandemic affecting globally. It has led to an unprecedented global health crisis assessing health system’s preparedness to deal with health disasters. The aim of our study was to evaluate the impact of COVID-19 on the follow up care of diabetic patients.Methods: We conducted a retrospective study in 100 insulin-requiring diabetic patients. Data regarding treatment availability, weigh, glycemic control and follow up ...

ea0081ep466 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Insulin analogs: do patients know their treatment advantages and modalities?

Bornaz Emna , Gharbi Radhouen , Ghram Lina , Chiboub Marwa , Kandara Hajer , Jemel Manel , Kammoun Ines

Introduction: In Tunisia, the prescription of insulin analogs is increasingly « automatic » by practicians, convinced by this treatment superiority over human insulin in diabetes management. The aim of our study is to determine whether the analogs prescription modalities and advantages are known by the patients, and to assess the factors associated with this knowledge.Patient and Methods: We conducted a retrospective study including 65 diabetic...

ea0081ep709 | Pituitary and Neuroendocrinology | ECE2022

A rare association of Neurofibromatosis type 2 and hypopituitarism

Ghram Lina , Gharbi Radhouen , Essayeh Sawsen , KANDARA Hajer , Jemel Manel , KAMMOUN Ines

Introduction: Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disorder that cause a growth of noncancerous tumors in the nervous system, it associates cranial schwannomas, meningiomas, and skin and ophthalmologic lesions. It is a rare condition and its association with an intrasellar arachnoidocele has not been reported yet. We report the case of a patient who presents a NF2 associated with hypopituitarism related to an intrasellar arachnoidocele.<p class="...

ea0081ep956 | Thyroid | ECE2022

Dosing study of brand vs. generic levothyroxine in well-controlled primary hypothyroidism

Kamoun Elyes , Jemel Manel , Gharbi Radhouen , Mkaouer Samir , Kandara Hajer , Kammoun Ines

Introduction: Most brand-name drugs do not differ that much from their generic counterparts, so switching between the two is not an issue. Levothyroxine, however, is an exception. The question of generic equivalency of levothyroxine products has remained unanswered for several decades. The purpose of the present study was to learn whether there is a difference of dosage between brand-name and generic levothyroxine in patient with well controlled primary hypothyroidism<p cl...