Searchable abstracts of presentations at key conferences in endocrinology

ea0022p290 | Diabetes | ECE2010

Response of interleukin-6 during euglycaemic and hyperglycaemic exercise in patients with type 1 diabetes mellitus

Jenni Stefan , Wueest Stephan , Konrad Daniel , Stettler Christoph

Background: Secretion of IL-6 during exercise is hypothesised to be regulated according to substrate availability within the working muscle. We have previously shown that energy supply in type 1 diabetes during aerobic exercise in hyperglycaemia strongly relies on carbohydrate oxidation whereas a physiological shift from carbohydrate to lipid oxidation occurs in euglycaemia. The present study investigated whether IL-6 response to exercise is different in euglycaemia compared w...

ea0041gp53 | Cardiovascular endocrinology | ECE2016

Different repletion of intramyocellular lipid (IMCL) in patients with growth hormone deficiency (GHD) compared to control subjects (CS) 24 h after a 2-h aerobic exercise

Jenni Stefan , Loher Hannah , Bucher Julie , Ith Michael , Boesch Chris , Kreis Roland , Christ Emanuel R

Background: We and others have shown that ectopic lipids are flexible fuel stores in healthy subjects, in patients with type 1 diabetes or with GHD. IMCL are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. It is unclear whether the exercise-induced flexibility of IMCL and IHCL persists until 24 h and whether healthy subjects and patients with GHD behave differently.Methods: Ma...

ea0037ep1115 | Endocrine tumours | ECE2015

Multifocal insulinomas (insulinomatosis) in GLP-1-receptor PET/CT

Jenni Stefan , Antwi Kwadwo , Fani Melponemi , Wild Damian , Heye Tobias , Gloor Beat , Perren Aurel , Christ Emanuel

Introduction: Apart from occurring sporadically, insulinoma within the framework of multiple endocrine neoplasia 1 (MEN-1) is well known. The rare presence of multifocal insulinomas has recently been assigned a separate entity (insulinomatosis). The difficulty of localising insulinomas may be improved by GLP1-receptor imaging.Case report A 48-year-old woman had been treated for suspected epileptic seizures for 2 years (lamotrigine). During another such e...

ea0022p306 | Diabetes | ECE2010

Exercise-related levels of acetylcarnitine in skeletal muscle of individuals with type 1 diabetes in Eu- and hyperglycaemia assessed by 1H-MR spectroscopy

Jenni Stefan , Boss Andreas , Kreis Roland , Ith Michael , Christ Emanuel , Boesch Chris , Stettler Christoph

Background: Acetylcarnitine (AC) is involved in intramyocellular fuel metabolism during exercise. So far, little is known on exercise-associated myocellular AC levels in patients with type 1 diabetes. In particular, it is unknown whether AC levels differ according to glucose values in diabetic patients. 1H magnetic resonance spectroscopy (MRS) of the skeletal muscle allows for the non-invasive assessment of acetylcarnitine (AC) accumulation. The present study assess...

ea0014p104 | (1) | ECE2007

Bone density in patients with non-functioning pituitary adenomas (NFA)

Fischli Stefan , Stettler Christoph , Sahli Rahel , Schwab Silvia , Chappuis Bernard , Jenni Stefan , Diem Peter , Christ Emanuel

Background: Surgically treated patients with NFA often present with secondary hypogonadism. Hypogonadism is a well known risk factor for osteopenia or osteoporosis. The aim of this study was to assess (a) the frequency of osteopenia/osteoporosis in a single centre Swiss cohort of patients with operated NFA and (b) whether gender or hypogonadism impacts on bone density at follow up.Methods: Data of patients with NFAs diagnosed between 1967 and 2005 were a...

ea0044oc1.5 | Early Career Oral Communications | SFEBES2016

A missense mutation in the islet-enriched transcription factor MAFA leads to familial insulinomatosis and diabetes

Iacovazzo Donato , Flanagan Sarah E. , Walker Emily , Caswell Richard , Brandle Michael , Johnson Matthew , Wakeling Matthew , Guo Min , Dang Mary N. , Gabrovska Plamena , Niederle Bruno , Christ Emanuel , Jenni Stefan , Sipos Bence , Nieser Maike , Frilling Andrea , Dhatariya Ketan , Chanson Philippe , de Herder Wouter , Konukiewitz Bjorn , Kloppel Gunter , Stein Roland , Ellard Sian , Korbonits Marta

Introduction: Insulinomatosis is a rare disorder characterised by persistent hyperinsulinaemic hypoglycaemia (PHH) due to the occurrence of multifocal pancreatic insulinomas. This condition, whose pathogenesis is unknown, can occur in a familial setting. Paradoxically, while some family members develop PHH, others develop diabetes mellitus.Methods: We have identified a family with autosomal dominant familial insulinomatosis and diabetes. Exome sequencing...