Searchable abstracts of presentations at key conferences in endocrinology

ea0031oc3.3 | Reproduction, growth and development | SFEBES2013

Regulation of G protein-coupling specificity via cis and trans activation of the LH/chorionic gonadotrophin receptor (LHCGR)

Jonas Kim , Muller Adolfo Rivero , Chou Yen Yin , Ji Tae , Hanyaloglu Aylin

Accepted dogma once stated that G protein-coupled receptors (GPCRs) function as monomers, however, over the last decade in vitro experiments have shown GPCRs to function as dimers and higher order oligomers. We have recently reported the first in vivo evidence for the physiological importance of Class A GPCR homodimerisation using the LHCGR as a model receptor. Transgenic co-expression of binding deficient LHCGR (LHCGR-LH) and signalling deficient ...

ea0028p279 | Reproduction | SFEBES2012

Dimerisation of luteinising hormone/chorionic gonadotrophin receptor (LHCGR); impact on intracellular signaling responses and ligand specificity

Jonas Kim , Rivero-Muller Adolfo , Chou Yen-Yin , Ji Tae , Hanyaloglu Aylin , Huhtaniemi Ilpo

G protein-coupled receptors (GPCRs) are one of the largest families of the mammalian genome, mediating the effects of approximately 40% of prescribed drugs. Until recently, accepted dogma stated that GPCRs exist as monomers, however, it is becoming evident that GPCRs can form higher order dimer/oligomer complexes which provide important mechanisms for the diversification of receptor function. The LHCGR is a class A family GPCR, primarily coupling to the Gαs pat...

ea0022h1.4 | Oral Communications Highlights 1 | ECE2010

Physiological rescue by functional complementation of mutated LH receptors in transgenic mice

Rivero-Muller Adolfo , Chou Yen-Yin , Lajic Svetlana , Hanyaloglu Aylin , Jonas Kim , Rahman Nafis , Ji Tae , Huhtaniemi Ilpo

The LH receptor (LHR) is a 7-transmembrane domain G-protein coupled receptor (GPCR) mainly expressed in the gonads with a major role in the development and maintenance of gonadal steroidogenesis and gametogenesis. Its ligand LH, secreted by the pituitary gland, binds to the extracellular domain of LHR triggering a conformational change in the transmembrane domain and leading to activation of intracellular signalling cascades.As a member of the GPCR famil...