ea0029p808 | Endocrine tumours and neoplasia | ICEECE2012
Morcavallo A.
, Genua M.
, Palummo A.
, Kletvikova E.
, Jiracek J.
, Brzozowski A.
, Iozzo R.
, Belfiore A.
, Morrione A.
Introduction: The isoform A of the human insulin receptor (IR-A) binds insulin with high affinity, and binds IGF-II with a 310 folds lower affinity. Cells lacking the insulin-like Growth Factor-I receptor (IGF-IR) and overexpressing the human IR-A (R-/IR-A cells) respond to IGF-II with reduced metabolic effects but unaltered or increased mitogenesis as compared to insulin stimulation. We hypothesized that this altered ratio of metabolic-to-mitogenic effects of IGF-II in ...