Searchable abstracts of presentations at key conferences in endocrinology

ea0035p461 | Diabetes complications | ECE2014

Diabetes and end-stage renal disease: clinical evaluation of diabetic renal transplant candidates

Dantas Rosa , Bastos Margarida , Saraiva Joana , Moreno Carolina , Guelho Daniela , Vicente Nuno , Cardoso Luis Miguel , Simoes-Pereira Joana , Guimaraes Joana , Alves Rui , Carrilho Francisco

Introduction: Diabetes mellitus (DM) is one of the main causes of end-stage renal disease (ESRD). Renal transplantation is the most effective form or renal replacement.Methods: Retrospective, descriptive study of a sample of 108 diabetic patients admitted as candidates to renal transplant from January 1991 to December 2011, using the SPSS programme, version 20.0.Results: 11 women and 97 men were evaluated (medium age: 58±8.2 y...

ea0037ep1306 | Clinical Cases–Thyroid/Other | ECE2015

Takotsubo cardiomyopathy associated with levothyroxine over-replacement

Balsa Ana Margarida , Ferreira Raquel , Dantas Rosa , Guimaraes Joana

Background: Takotsubo cardiomyopathy (TC) is characterised by acute, transient left ventricular apical ballooning precipitated by emotional or physiologically stressful stimuli and has been previously associated with Graves’ disease based on few clinical reports. More recently, the association with exogenous thyrotoxicosis and radioiodine-induced thyroiditis has also been described. Iatrogenic hyperthyroidism on patients under levothyroxine replacement therapy for hypothy...

ea0049ep106 | Adrenal medulla | ECE2017

Loss diagnosis of pheochromocytoma in the initial evaluation

Azevedo Teresa , Alves Marcia , Guimaraes Joana , Dantas Rosa , Balsa Ana Margarida , Inacio Isabel

Introduction: In most cases, adrenal masses are non-functioning adrenocortical adenomas. On ‘Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline’ published in 2016, the experts ‘suggest against repeated hormonal work-up in patients with a normal hormonal work-up at initial evaluation unless new clinical signs of endocrine activity appear or there is worsening of comorbidities’.C...

ea0059p057 | Clinical biochemistry | SFEBES2018

Genetic susceptibility to type 1 diabetes: genomic variants in the vitamin D pathway

Almeida Joana , Rodrigues Dircea , Carrilho Franscisco , Guimaraes Joana , Lemos Manuel C

Type 1 diabetes mellitus (T1D) is an autoimmune disease that results from the destruction of insulin producing β cells, in genetic susceptible individuals. Vitamin D (Vit D) is mostly known for its role in bone and calcium metabolism, however it is also involved in the modulation of the immune response. Serum levels of vitamin D partly depend on diet and sunlight exposure. However, genetic factors are also involved. Patients with T1D have been reported to have a higher pr...

ea0014p464 | (1) | ECE2007

Cushing’s syndrome in paediatric age – casuistic, evolution of investigation tests and treatment options in our institution throughout the last 20 years

Melo Miguel , Fagulha Ana , Paiva Isabel , Guimaraes Joana , Baptista Carla , Gomes Fernando , Belo Francisco , Carvalheiro Manuela

Cushing’s syndrome is a rare disorder in children and adolescents. The diagnosis can be a challenge for the clinician, as its principal feature – obesity – is extremely common. We present three cases diagnosed in the last 20 years. The first one was a boy aged 17 that presented in 1984 with central obesity, acne, moon face with plethora, abdominal striae, easy bruising and skin atrophy. The investigations performed consisted in cortisol and ACTH plasma measureme...

ea0063p906 | Diabetes, Obesity and Metabolism 3 | ECE2019

Gestational Diabetes in Early Pregnancy – what does fasting glucose tell us?

Rosinha Patricia , Dantas Rosa , Alves Marcia , Azevedo Teresa , Inacio Isabel , Ferreira Sara Esteves , Pedrosa Carla , Albuquerque Isabel , Garrett Ana Catarina , Guimaraes Joana

Introduction: The association of fasting glucose (FG) in early pregnancy (EP) with adverse outcomes for the mother and her offspring is well known, although the best cut-offs for diagnosis of Gestational Diabetes (GD) are not consensual.Objetive: Evaluate the impact of FG in EP in the management of pregnant women and obstetric and fetal outcomes.Methods: Retrospective cohort of pregnant women with GD diagnosed before 24 weeks of ge...

ea0063p910 | Diabetes, Obesity and Metabolism 3 | ECE2019

Gestational Diabetes: what to say about body mass index and outcomes? The influence of prepregnancy body mass index on obstetric and neonatal outcomes of women with gestational diabetes

Ferreira Sara Esteves , Rosinha Patricia , Inacio Isabel , Alves Marcia , Azevedo Teresa , Dantas Rosa , Pedrosa Carla , Ferreira Marilia , Albuquerque Isabel , Fonseca Catarina , Jesus Andreia , Guimaraes Joana

Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy, leading to adverse neonatal and obstetric outcomes.Objective: To evaluate the influence of maternal prepregnancy body mass index (BMI) on blood glucose levels at diagnosis of gestational diabetes (GD), obstetric and neonatal outcomes.Methods: Retrospective observational study including women with GD and singleton pregnancy, with fo...

ea0063p989 | Diabetes, Obesity and Metabolism 3 | ECE2019

Metformin and Vitamin B12 deficiency: evaluation of vitamin B12, homocysteine and methylmalonic acid levels in type 2 diabetics

Inacio Isabel , Azevedo Teresa , Alves Marcia , Dantas Rosa , Balsa Ana Margarida , Ferreira Sara , Rosinha Patricia , Gomes Fernanda , Fonseca Catarina , Garret Ana , Jesus Andreia , Guimaraes Joana

Introduction: The American Diabetes Association guideline states that the long-term use of metformin may be associated with biochemical vitamin B12 (B12) deficiency and periodic measurement should be considered, although isolated serum B12 measurement has low sensitivity and specificity. Homocysteine (Hcy) and methylmalonic acid (MMA) are more sensitive biomarkers, the latter being more specific.Objectives: To estimate B12 deficiency in type 2 diabetics ...

ea0037ep195 | Reproduction, endocrine disruptors and signalling | ECE2015

Klinefelter syndrome: a small sample retrospective analysis

Balsa Ana Margarida , Bastos Margarida , Moreno Carolina , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Alves Marcia , Guimaraes Joana , Carrilho Francisco

Introduction: Klinefelter syndrome (KS) is characterized by the presence of supernumerary X-chromosome and thus a 47,XXY karyotype. This syndrome remains underdiagnosed, with only about 25% of patients being identified, and only 10% during childhood.Methods: Retrospective analysis of 11 KS patients followed-up in the Endocrinology Department of Coimbra’s Hospital and Universitary Center. The registered data included education and occupation, time an...

ea0037ep1154 | Clinical Cases–Pituitary/Adrenal | ECE2015

A case report of Langerhan cells histiocytosis – the need for a good transition care

Balsa Ana Margarida , Bastos Margarida , Moreno Carolina , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Alves Marcia , Guimaraes Joana , Carrilho Francisco

Introduction: Langerhan Cells Histiocytosis (LCH) is a rare heterogeneous idiopathic clinical entity involving clonal proliferation of Langerhan cells that may infiltrate most commonly bone, skin, lymph nodes or lungs. It affects mainly children between 5 and 15 years. The most common endocrine manifestation is diabetes insipida.Clinical case: The authors describe a case of a 19-year-old female patient, admitted in the Transition Follow-up of the Endocri...