Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc11.5 | Rapid Communications 11: Thyroid 2 | ECE2022

Which factors can influence the occurrence of two nondiagnostic results in fine-needle aspiration cytology of the same thyroid nodule?

Cosme Ines , Silvestre Catarina , Joao Bugalho Maria

Introduction: Fine-needle aspiration cytology (FNAC) of thyroid nodules can be associated with non-diagnostic (ND) results, despite the usage of ultrasound (US) guidance. It is recommended to repeat the FNAC because of the possible risk of malignancy in these nodules.Aim: To evaluate the influence of demographic, clinical and echographic characteristics in the recurrence of ND FNAC in a thyroid nodule.Methods: Retrospective review ...

ea0081p350 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of autoantibodies in paediatric and adult patients with type 1 diabetes mellitus – study of a Portuguese cohort

Cosme Ines , Silvestre Catarina , Nunes Daniel , Lemos Carlos , Joao Bugalho Maria , Proenca Helena

Introduction: Almost all type 1 diabetes mellitus (T1DM) patients have autoantibodies (ab) at disease onset. These ab prevalence varies according to patients’ age, origin and disease duration.Aim: Determine diabetes mellitus ab prevalence in a paediatric and adult T1DM Portuguese according to their age on diagnosis, gender and diabetes duration.Methods: Retrospective review of T1DM ab (glutamic acid decarboxylase 65 autoantibo...

ea0049ep329 | Clinical case reports - Thyroid/Others | ECE2017

Autosomal dominant hypocalcemia in a Portuguese family: novel mutation in the calcium-sensing receptor gene

Gomes Vania , Ferreira Florbela , Silvestre Catarina , Castro Raquel , Joao Bugalho Maria

Introduction: Autosomal dominant hypocalcemia (ADH) is a rare condition, caused by activating mutations in the calcium-sensing receptor (CASR) gene. Affected individuals have hypocalcemia with inappropriately low parathyroid hormone (PTH) levels.Case report: A 50-year-old woman, asymptomatic, was referred to our Endocrinology department for investigation of hypocalcemia detected in routine blood analysis (serum corrected calcium was 7.4 mg/dl &#...

ea0049ep1055 | Pituitary - Clinical | ECE2017

Hypogonadotropic hypogonadism in a patient with long-term primary hypothyroidism

Vaz de Castro Raquel , Maria Aragues Jose , Ferreira Florbela , Gomes Vania , Wessling Ana , Joao Bugalho Maria

Abstract: We report the case of a 65-year-old man who presented with erectile dysfunction to an appointment in our Endocrinology department. He referred fatigue, weight gain and constipation as secondary complaints that had been steadily evolving throughout the past 4 years. He denied other symptoms such as visual impairment or headaches as well as the consumption of any medications or drugs. His past medical history was unremarkable. On examination, BMI was 25.8 kg/m2</s...

ea0022p413 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Von Hippel-Lindau disease: a case report

Gouveia Sofia , Ribeiro Cristina , Paiva Sandra , Joao Bugalho Maria , Santos Jacinta , Vieira Alexandra , Alves Marcia , Carvalheiro Manuela

Introduction: Von Hippel-Lindau disease (VHLD) is a rare autosomal-dominant syndrome, characterized by the development of multiple cysts and tumours, namely retinal and central nervous system hemangioblastomas, renal cell carcinoma (RCC), phaeochromocytoma, pancreatic endocrine tumours (PET) and endolymphatic sac tumours.Most germinal mutations are missense, related to a high risk for presenting phaechromocytoma (specially if Arg167Trp mutation im...

ea0056p517 | Diabetes therapy | ECE2018

Long-term results of continuous subcutaneous insulin infusion on glycemic control and severe hypoglycemias

do Vale Sonia , Carvalho Raquel , Matos Tania , Costa Cristiana , Filipa Martins Ana , Silvestre Catarina , Joao Bugalho Maria

Introduction: The use of Continuous Subcutaneous Insulin Infusion (CSII) is expected to improve glycemic control and to reduce hypoglycemia events. However, long-term beneficial results in glucose control are not always observed. We evaluated long-time glucose control and severe hypoglycemias in type 1 diabetic patients using CSII, without continuous glucose monitoring.Patients and methods: This was a retrospective study of adult type 1 diabetic patients...

ea0056ep120 | Pituitary and Neuroendocrinology | ECE2018

Macroprolactinoma found in obesity setting: case report

Sofia Osorio Ana , Filipa Martins Ana , Vieira Joao , Barbosa David , Faria Carolina , Nobre Ema , Joao Bugalho Maria

Obesity is growing fast worldwide. Although environmental factors play a major role, endocrine dysfunction may contribute to the weight gain. We report an invasive macroprolactinoma diagnosed in obesity setting. A 35-year-old male was referred to our endocrine outpatient department due to grade 2 obesity (IMC 38.4 Kg/m2). His weight was increasing since the beginning of his professional activity at the age of 20 due to a sedentary lifestyle. On physical examination he had an h...

ea0049ep791 | Endocrine tumours and neoplasia | ECE2017

Polyglandular autoimmune syndrome type III b

Vaz de Castro Raquel , Maria Aragues Jose , Ferreira Florbela , Gomes Vania , Wessling Ana , Tavares Lurdes , Ribeiro Joana , Alves Irina , Camilo Fernandes Afonso , Joao Bugalho Maria

: We report the case of a 57-year-old female diagnosed with Grave’s disease fifteen years before (TSH <0.001 U/ml; FT4 2.3 ng/dl; FT3 7.2 ng/dl, TSAbs 17 U/l). Persistency of hyperthyroidism despite antithyroid therapy led to total thyroidectomy three years after the diagnosis. Thereafter, thyroid function remained normal under hormonal replacement with levothyroxine. The patient had also been diagnosed with Pernicious Anemia at 47 years of age after investigation for...

ea0056p1076 | Thyroid (non-cancer) | ECE2018

Effectiveness of radioiodine treatment for toxic adenoma

Sofia Osorio Ana , Filipa Martins Ana , Vaz de Castro Raquel , Gomes Vania , Faria Carolina , Nobre Ema , Antoine Ferreira Mickael , Cantinho Guilhermina , Joao Bugalho Maria

Objective: The purpose of this study was to assess clinical outcomes of patients with toxic adenoma (TA) treated with Radioactive Iodine (RAIT) in a tertiary hospital over a period of 8 years. We also analysed the influence of age, gender, TSH at diagnosis and anti-thyroid drugs (ATD) previous to RAIT on the cure rate.Methods: Retrospective analysis of clinical records of all patients with TA submitted to RAIT between 2008 and 2015. The influence of demo...

ea0084ps2-10-95 | Nodules & Cancer | ETA2022

Contribution of cyto-histological genetic profile to a precocious diagnosis in thyroid neoplasm

De Lurdes Godinho De Matos Maria , pinto mafalda , Alves Marta , Canberk Sule , Boaventura Paula , Goncalves Ana , Luisa Papoila Ana , Joao Bugalho Maria , Soares Paula

Introduction: The diagnostic gold standard for thyroid nodular disease is ultrasound-guided fine-needle aspiration cytology (US-FNAC), being the most accurate, cost-effective and minimal invasive preoperative test to distinguish benign from malignant nodules, aiming to resolve patient management. However, up to 30% of FNACs are classified as indeterminate nodules, turning difficult the decision on patient management to avoid unnecessary surgeries. The development of thyroid ca...