Searchable abstracts of presentations at key conferences in endocrinology

ea0032p863 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

How to get surgical remission rates in ACTH- and GH-microadenomas to 100%

Ludecke Dieter , Flitsch Joerg , Crock Patricia , Saeger Wolfgang

Introduction: Pharmacological treatments are available for all functioning pituitary adenomas, but found to be only ideal in prolactinomas. Therefore, at least in ACTH- and GH-microadenomas we have to strive to achieve 100% remission with transnasal surgery. Our question is, which combination of an increasing arsenal of pre- and peri-operative methods will bring the pituitary surgeons to this result without increasing complications.Materials and methods:...

ea0049gp176 | Pituitary | ECE2017

Minimally Invasive Diagnosis and Direct Transnasal Surgery: a single centre series of 100 children with Cushing’s Disease with long term follow-up

Crock Patricia , Ludecke Dieter K , Knappe Ulrich , Flitsch Joerg , Saeger Wolfgang

Introduction: Trans-sphenoidal surgery (TSS) with minimally invasive techniques is the first choice in the treatment of paediatric Cushing’s disease (CD). The question is how can high remission rates be achieved with less invasive investigations and TSS. The developments in our centre treating 100 pediatric Cushing patients with long-term follow-up may add some helpful ideas.Material and methods: Data from our first series 1 (n=55) will be ...

ea0041oc9.5 | Endocrine Tumours | ECE2016

Pituicytoma: a neuropathological analysis of 10 samples

Mende Klaus Christian , Matschke Jakob , Buslei Rolf , Buchfelder Michael , Fahlbusch Rudolf , Saeger Wolfgang , Flitsch Joerg

Introduction: Pituicytoma is a rare neoplasm of the sellar region, believed to originate from neurohypophyseal cells. Tumor resection is the primary treatment option, but may remain incomplete due to excessive bleeding of the well vascluarized tumor stroma. Therefore the search for alternative or additional treatment regimens is necessary. In a previous publication in 2012 the presence of VEGF-R was shown in one tumor sample, potentially opening the door for modern treatment o...

ea0056gp197 | Pituitary Basic | ECE2018

Efficacy of pharmacological USP8 inhibition in human Cushing’s disease tumours in vitro

Theodoropoulou Marily , Perez-Rivas Luis , Albani Adriana , Stalla Gunter , Buchfelder Michael , Flitsch Joerg , Honegger Juergen , Rachinger Walter , Reincke Martin

The tumorigenesis of Cushing’s disease is characterized by somatic mutations in the USP8 gene in almost half of the cases. USP8 encodes for ubiquitin specific protease 8, a deubiquitinase that rescues proteins involved in the regulation of ACTH synthesis in corticotroph cells. In the present study we tested the antisecretory and antiproliferative efficacy of a commercially available specific USP8 inhibitor (IC50 3.1 μM USP8; >90 μM USP7) in immortalized muri...