Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc7.4 | IGF-1 and Thyroid Basic | ECE2014

Training MCT10 to transport thyroxine: Structure based targeted mutations in MCT10

Schweizer Ulrich , Braun Doreen , Johannes Jorg

With the identification of mutations in the monocarboxylate transporter 8 (MCT8) gene in patients afflicted with the Allan–Herndon–Dudley syndrome (AHDS), the concept of transporter-mediated transmembrane transport of thyroid hormones was finally accepted. Impaired thyroid hormone transport into neurons and pituitary cells is believed to cause severe psychomotor retardation and altered thyroid hormone function tests. MCT8 is a specific thyroid hormone transporter abl...