Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc4.5 | Neuroendocriology basis | ECE2007

Lack of nuclear Hes1 expression coincides with transformation of endocrine pancreatic cells in Men1 knock out mice

Johansson Térèse , Lejonklou Margareta Halin , Skogseid Britt

Background: Homozygous inactivation of the MEN1 tumor suppressor gene frequently occurs in endocrine pancreatic tumors (EPT); however, a heterozygous germ line inactivation of the gene seems to lead to development of an increase amount of endocrine pancreatic cells. The Notch signaling cascade plays a vital role in sustaining the balance between cell proliferation, differentiation and apoptosis during pancreatic development. Whether Notch signaling is MEN1 depend...

ea0014p108 | (1) | ECE2007

Ascl1 is abundantly expressed in endocrine pancreatic tumors

Johansson Téresè , Halin Lejonklou Margareta , Ekeblad Sara , Stålberg Peter , Skogseid Britt

Background: Apart from inactivation of the MEN1 gene, molecular events essential for tumorigenesis of the endocrine pancreas are poorly characterized. A potentially useful approach for understanding tumor progression is to study transcription factors operating in fetal pancreatic development. The Notch signaling cascade with expression of the transcription factors Hes1, Hey1, and Ascl1 plays a vital role in sustaining the balance between cell prolif...