Searchable abstracts of presentations at key conferences in endocrinology

ea0019p283 | Reproduction | SFEBES2009

Metabolic effects of insulin and modification by androgen in immortalised mouse granulosa cells

Joharatnam J , Hardy K , Franks S

Polycystic ovary syndrome (PCOS) is characterised by hyperandrogenism and insulin resistance. It is thought that androgen excess contributes to the mechanism of insulin resistance. Granulosa cells in PCOS demonstrate impaired insulin-induced glucose uptake and lactate accumulation1. The aim of this study was to characterise insulin signalling (via the PI3-Kinase (PI3-K) pathway) and glucose metabolism in an immortalised mouse granulosa cell line (KK1)2, a...