Searchable abstracts of presentations at key conferences in endocrinology

ea0069p30 | Poster Presentations | SFENCC2020

ADHD and Addison’s: similar in name, similar in nature?

Yin Su Lei , Solomon Andrew , Joharatnam Jalini

Section 1: Case history: An 18 year old young man with a background of several years’ ADHD (Attention Deficit Hyperactivity Disorder) and moderate learning disability presented generally unwell, with recent weight loss, abdominal pain, vomiting and poor oral intake in May 2019. He had been unsettled for some time with his mother convinced that his current condition warranted further investigation. When blood tests were done, severe hyponatraemia and hyperkalaemia were fou...

ea0069p50 | Poster Presentations | SFENCC2020

Pregnancy against the odds

Yin Yin , Lin Nyan , Joharatnam Jalini

A 17-year-old young lady presented with tiredness, weight loss, palpitations, hot flushes and irregular menstruation in April 2016 and her initial TFTs showed TSH <0.03 mU/l with a fT4 of 48.2 pmol/l. She was treated with carbimazole 40 mg daily and further investigation confirmed she had had Graves’ disease as TSH receptor antibodies (2.10 U/l), TPO antibodies (>1300 IU/ml), thyroid ultrasound scan demonstrated mildly enlarged and thyroiditis. She had only six period...

ea0062p44 | Poster Presentations | EU2019

Pituitary metastasis masquerading as a non-functioning pituitary macroadenoma

Sheikh Anum , Zac-Vargheses Sagen , Joharatnam Jalini

Case History: A female, aged eighty-three was admitted for an elective urology stent procedure. She had a background history of a non-functioning pituitary adenoma diagnosed 3 weeks before admission. This was found after investigation for headache and diplopia. The pituitary lesion was described as 18 × 17 × 14 mm in size and mixed solid/cystic in nature. There was no chiasmal compression. During that admission her case was discussed with neurosurgery and it was felt...

ea0025p35 | Clinical biochemistry | SFEBES2011

The short Synacthen test (SST): should we be testing at both 30 and 60 min?

Carroll Richard , Joharatnam Jalini , Todd Jeannie

The short Synacthen test (SST) is used to evaluate adrenal glucocorticoid secretion in response to synthetic ACTH (also known as tetracosactide or Synacthen). Traditionally, after a baseline cortisol and ACTH, two plasma cortisol samples have been taken after i.v. or i.m. administration of Synacthen 250 μg, one at 30 min and one at 60 min. However practice varies and some physicians only take one cortisol measurement at 30 min.Hypothesis: A protocol...

ea0015p21 | Clinical practice/governance and case reports | SFEBES2008

Tereparatide for treatment of hypoparathyroidism

Joharatnam Jalini , Peters Debbie , Meeran Karim

A 51-year-old gentleman underwent a thyroidectomy 7 years ago for a benign multinodular goitre. Unfortunately, as a consequence of the surgery he became hypocalcaemic secondary to hypoparathyroidism. He was commenced on calcichew 1 tablet daily, calcium carbonate ‘500’ twice daily, vitamin D injections and 1- alphacalcidol 1 mcg daily. Initially, his PTH remained detectable and therefore it was hoped there would be some recovery, but over time this was proven not to ...

ea0034p404 | Thyroid | SFEBES2014

Thyroid nodules: Is one robust Thy2 result sufficient?

Joharatnam Jalini , Ngu Rose , Chandra Ash , Powrie Jake

Introduction: Approximately 400 thyroid fine needle aspirates (FNAs) are performed annually at our institution. Many are repeat aspirates of Thy2 results. Current British Thyroid Association (BTA) and Royal College of Pathologists (RCPath) guidelines recommend two FNAs performed at least 6 months apart to confirm a benign result. Our aim was to investigate whether one Thy2 result is sufficient to confirm benign pathology.Method: A retrospective analysis ...

ea0028p370 | Thyroid | SFEBES2012

Acute bulbar palsy in association with Graves thyrotoxicosis

Abbara Ali , Chhina Navpreet , Joharatnam Jalini , Todd Jeannie , Williams Graham

A 77 year old man with a background of Crohns disease requiring ileostomy, pernicious anaemia and hypertension, presented with a 4month history of dysphagia to solids, hoarseness of voice, anorexia and marked weight loss of 30 kg. He was initially referred to gastroenterology, who performed an endoscopy which was normal. Subsequently he was referred to the ENT and speech and language therapy departments. A video fluoroscopy confirmed severe oropharyngeal dysphagia with effortf...

ea0028p372 | Thyroid | SFEBES2012

Langerhans cell histiocytosis and Graves’ disease

Abbara Ali , Chhina Navpreet , Joharatnam Jalini , Tharakan George , Todd Jeannie

A 27 year old lady with a background of Langerhans cell histiocytosis (LCH) presented to endocrinology clinic for investigation of thyrotoxicosis. At the age of three years old, she presented with a rash on her forehead, which on biopsy revealed Langerhans cell histiocytosis. She was also noted to have symptoms consistent with diabetes insipidus, for which she remains on desmopressin therapy. At the age of six she received pituitary radiotherapy and 6 years ago developed secon...

ea0028p381 | Thyroid | SFEBES2012

Alemtuzamab induced thyrotoxicosis

Chhina Navpreet , Abbara Ali , Joharatnam Jalini , Todd Jeannie

A 60year old gentleman was referred to endocrine team with new onset hyperthyroidism. He had developed tubulointerstitial nephritis secondary to carbamazepine resulting in ESRF 3 years previously. Four months prior to presentation he received a live-unrelated renal transplant including a single dose of Alemtuzamab post-operatively for induction of immunosuppression. Thereafter his immunosuppression was maintained with tacrolimus. Other medical history included bipolar disorder...

ea0021p314 | Reproduction | SFEBES2009

GLUT4 expression and translocation in immortalised mouse granulosa cells

Joharatnam Jalini , Skodras Angelos , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) is associated with insulin resistance. Abnormally low glucose transporter 4 (GLUT4) expression has been shown in adipocytes from subjects with PCOS1 and skeletal muscle from type 2 diabetics2. Although GLUT4 expression is mostly restricted to classic insulin target tissues such as skeletal muscle, cardiac muscle and adipose, we have found it in granulosa cells (GCs) of mice3. Glucose uptake and metabolism by GCs...