ea0013s73 | Nuclear hormone receptor-chromatin interactions: new approaches and insight into dynamics | SFEBES2007
Hager Gordon
, Johnson Thomas
, Schiltz R Louis
, Wiench Malgorzata
, Stavreva Diana
, Voss Ty
, Sung Myong-Hee
, John Sam
In response to hormone activation of the glucocorticoid receptor, GR responsive promoters move through a complex series of activity states, a phenomenon we term promoter progression. Genome-wide profiling of glucocorticoid receptor (GR) regulated loci reveals several classes of response, including genes that are transiently activated and genes that are transiently repressed. In contrast to the conventional paradigm of activation and repression, GR modulation of genome function...