Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc4.3 | Bone and adrenal | ECE2008

BMP dependent modulation of adrenocortical growth and function

Johnsen Inga K , Spady Lilia , Shapiro Igor , Beuschlein Felix

Bone morphogenic proteins (BMPs) have been demonstrated to impact tumorigenesis in a variety of tumors. As for the adrenal cortex, BMP6 has been implicated as an important modulator of aldosterone secretion. To screen for alterations of BMP dependent pathways in adrenal tumorigenesis we performed gene profiling experiments. By comparing human adrenal carcinoma (ACC) against normal adrenal glands (Co) we detected a down-regulation of various BMPs (e.g. BMP2, BMP5) which was fur...