Endocrine Abstracts

Hyperthyroid cats have elevated parathyroid hormone (PTH) concentrations and suppressed fibroblast growth factor-23 (FGF-23) concentrations, both of which normalise following treatment of hyperthyroidism. PTH, FGF-23, and thyroid hormone can influence the renal reabsorption of calcium and phosphate. The aim of the present study was to assess the influence of hyperthyroidism on renal tubular function in cats indirectly, by comparing the FE of electrolytes in hyperthyroid cats w...

Cats are the only species, other than humans, in which naturally occurring, non-malignant hyperthyroidism has been recorded. Feline hyperthyroidism has many similarities to toxic nodular goitre, including age at risk, presentation, histological features and similar ‘switch-on’ mutations of the TSH receptor and linked G-proteins. Subclinical hyperthyroidism is well recognised in humans but has only recently been described in cats. We present preliminary data from a pr...

Background: Endocrinopathic laminitis is a painful equine condition that may cause persistent lameness warranting euthanasia. Hypoadiponectinemia and insulin dysregulation (ID, manifesting as hyperinsulinemia, tissue insulin resistance (IR), and/or excessive insulin responses to non-structural carbohydrates) are independently associated with increased laminitis risk, although underlying mechanisms remain unclear.Methods: This study aimed to investigate t...

Laminitis, an inflammatory condition of the sensitive and specialised architecture (the laminae) in the equine hoof, can be induced by over-ingestion of non-structural carbohydrates (NSC) from spring/summer pasture. Some equids that are predisposed to laminitis appear to share characteristics described in human patients with metabolic syndrome, such as vascular dysfunction, obesity, development of an inflammatory profile and insulin resistance. We investigated whether adipose ...

Laminitis, an inflammatory condition of the sensitive and specialised architecture (the laminae) in the equine hoof, can be induced by over-ingestion of non-structural carbohydrates (NSC) from spring/summer pasture. Some equids that are predisposed to laminitis appear to share characteristics described in human patients with metabolic syndrome. We investigated if adipose tissue from laminitis prone equids (LP) functions differently from non-laminitis prone equids (NL), by exam...

Tyrosine availability critically influences thyroid hormone synthesis, and thyroid disorders, such as hyperthyroidism, affect 1% of humans. In contrast, nearly 10% of mature/senior cats develop hyperthyroidism, but colourpoint breeds with mutations in the tyrosinase gene (e.g. Siamese) show reduced risk of developing hyperthyroidism, potentially due to increased availability of tyrosine (related to coat colouration). To establish how tyrosine availability can alter thyroid fun...