Searchable abstracts of presentations at key conferences in endocrinology

ea0038p247 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Is polycythaemia a marker of an increased cardiovascular risk in transmen?

Naing Aye , Lei Lily , Jones Katie , Barrett James , Seal Leighton

A retrospective single centre audit was conducted on the effects of polycythaemia in trans-male and native male.Polycythaemia is a recognised side effect of testosterone treatment. It could be viewed as a maker of excess testosterone action. We examined whether lipid profiles as a marker of cardiovascular risk differed in a population of polycythaemic transmen (TM) and native males (NM).Forty-six NM and 12 TM were identified to hav...

ea0085oc5.7 | Oral Communications 5 | BSPED2022

Salivary cortisol and cortisone in healthy children and young people

Dliso Silothabo , Park Julie , Jones Lily , Bright Orla , Shantsila Alena , Hawcutt Daniel , Lip Gregory , Blair Joanne

Background: Cortisol is inactivated to cortisone in the salivary gland by 11β-HSD type 2. Concentrations of cortisone and cortisone in saliva correlate strongly with serum cortisol concentrations (1). Only free, biologically active hormone is measured in saliva, testing is non-invasive and can be performed at home/school, reducing cost and inconvenience to families and NHS resources. We previously reported pilot data from healthy children and young people (CYP) (1). Here we de...

ea0085p3 | Adrenal 1 | BSPED2022

Mean glucose concentrations are increased, and cardiovascular risk factors are common in children and young people with secondary adrenal insufficiency (GRACE2)

Park Julie , Jones Lily , Dliso Silothabo , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Hypoglycaemia, possibly due to non-physiological hormone replacement, and poor cardiovascular outcomes are described in patients with adrenal insufficiency (AI), particularly in the adult population. In this study, we describe glucose profiles and risk factors for premature cardiovascular disease (CVD) in children with secondary AI (SAI).Methods: Participants underwent continuous glucose monitoring (CGM), for seven days (blinded Dexcom G6 mon...

ea0085p25 | Gonadal, DSD and Reproduction | BSPED2022

Salivary cortisol is increased in paediatric patients with turner syndrome, and the circadian rhythm is blunted: preliminary data from a pilot study

Jones Lily , Blair Joanne , Park Julie , Dliso Silothabo , Hawcutt Daniel , YH Lip Gregory , Shantsila Alena

Background: Increased hair cortisol concentrations are reported in Turner Syndrome (TS) patients compared to healthy controls (HC).(1) Increased cortisol exposure could contribute to cardiovascular, metabolic and bone morbidity in TS. Hair cortisol concentrations give no information about the circadian profile of cortisol, which is important for cardiovascular health. Cortisol is inactivated to cortisone by 11β hydroxysteroid dehydrogenase (11βHSD) type-2 and regener...

ea0085p2 | Adrenal 1 | BSPED2022

Salivary adrenal biomarkers differ depending on age and sex in healthy children: preliminary data

Park Julie , Jones Lily , Dliso Silothabo , Bright Orla , Walker Laura , Grasim Ionela , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Saliva is ideal for measuring free, biologically active hormones. Measurements of salivary androgens may be valuable in diagnosis and monitoring of adrenal disorders, however the diurnal profile and robust reference ranges in healthy children are currently undefined. We report salivary testosterone, androstenedione (A4), 11-ketotestosterone (11-KT), 11-β hydroxyandrostenedione (11β-OHA4) concentrations measured throughout the day in healthy children.<...