Searchable abstracts of presentations at key conferences in endocrinology

ea0005p142 | Endocrine Tumours and Neoplasia | BES2003

Cell cycle dysregulation in parathyroid adenoma and carcinoma

Valentine G , Jordan S , Lu X , Lowe D , Hirace R , Korbonits M , Grossman A

While primary hyperparathyroidism is most commonly due to a parathyroid adenoma, very occasionally it may be secondary to a parathyroid carcinoma. A substantial minority of parathyroid adenomas are due to mutations or transpositions in genes in involved in the regulation of the cell cycle. In particular, at the cell cycle checkpoint which regulates exit from G1 phase, there is an interaction between the cyclins and cyclin-dependent kinases (CDKs); specifically, cyclin D intera...

ea0002p61 | Neuroendocrinology | SFE2001

MIF (Macrophage Migration Inhibitory Factor) is over-expressed in the nucleus of pituitary adenoma cells

Pyle M , Jordan S , Gueorguiev M , Meinhardt A , Metz C , Bucala R , Korbonits M , Grossman A

MIF can override the anti-inflammatory actions of glucocorticoids during immune response, and thus is an important pro-inflammatory factor. The presence of MIF in the cytoplasm of adenomatous cells of the anterior pituitary has been described, and high levels of MIF in other rapidly-proliferating tissues have been demonstrated. It is hypothesized that MIF release from these cells is influenced by the hypothalamo-pituitary-adrenal axis, and that ACTH and MIF are released simult...