Searchable abstracts of presentations at key conferences in endocrinology

ea0020p595 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Growth hormone replacement therapy in adult onset growth hormone deficiency induces favorable long-term effects on quality of life, bone, body composition and lipids: a 55 month prospective study

Jorgensen Anders Palmstrom , Fougner Krisitan J , Schreiner Thomas , Bollerslev Jens

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

ea0081ep735 | Pituitary and Neuroendocrinology | ECE2022

Endocrine treatment of anabolic-androgenic steroid induced hypogonadism in males: A pilot study

Christian Bordado Henriksen Hans , Palmstrom Jorgensen Anders , Bjornebekk Astrid , Neupane Sudan Prasad , A. Havnes Ingrid

Background and aims: Non-prescribed use of anabolic-androgenic steroids (AAS) is associated with a wide range of health risks including AAS-induced hypogonadism (ASIH) caused by negative feedback suppression on the hypothalamic-pituitary-gonadal (HPG) axis. Testicular function might be reduced for months up to years after AAS-cessation, increasing the risk of developing fatigue, decreased libido, erectile dysfunction, infertility, sleep disorder, depression and anxiety. There ...

ea0063p1109 | Pituitary and Neuroendocrinology 3 | ECE2019

HPA axis function in patients with clinically non-functioning pituitary adenomas: effects of surgery and risk factors for HPA failure

Kolnes Anders Jensen , Oystese Kristin Astrid , Dahlberg Daniel , Bollerslev Jens , Jorgensen Anders Palmstrom

Introduction: Patients planned for first time surgery for clinically non-functioning pituitary adenoma (NFPA) were included in this prospective study.Aims: – To study the prevalence of hypothalamic-pituitary-adrenal (HPA) axis failure preoperatively and 3 months after surgery for clinically NFPA.– To investigate factors predicting risk of HPA axis failure postoperatively.Hypotheses<p class="abst...

ea0037ep766 | Pituitary: clinical | ECE2015

The metabolic relevance of angiopoietin-like protein 4 in different states of GH/IGF1 excess or deficiency

Olarescu Nicoleta Cristina , Jorgensen Anders P , Heck Ansgar , Normann Kjersti R , Godang Kristin , Bollerslev Jens

Context: Angiopoietin-like protein 4 (Angptl4) is a protein involved in lipolysis, that is regulated by non-esterified free fatty acids (FFA). GH promotes lipolysis and increases circulating FFA. Hypothesis: GH increases circulating Angptl4 levels by modulating its expression and secretion from fat and muscle. Angptl4 might be of metabolic relevance for the insulin resistance associated with GH/IGF1 excess or deficiency.Objective: To evaluate Angptl4 in ...

ea0022p639 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Sub-acute tumour debulking with somatostatin analogues in newly diagnosed acromegaly due to macroadenomas

Olarescu Cristina , Husby Oystein , Heck Ansgar , Ringstad Geir , Ramm-Pettersen Jon Terje , Jorgensen Anders Palmstrom , Bollerslev Jens

Background: Surgery is accepted as first line treatment of somatotroph macroadenomas with involvement of the optic chiasm. However, during recent years somatostatin analogues (SA) have increasingly been used as primary treatment improving ultimate cure rate, as SA’s have anti-proliferative effects in most tumours. We demonstrate here positive effect of subacute/acute SA treatment on tumour shrinkage and chiasm decompression in two recently diagnosed acromegalic patients.<...

ea0090oc4.2 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Inhibition of RANKL in the testis increased the number of motile sperm in a sub-group of infertile men with preserved Sertoli cell function

Hjorth Andreassen Christine , Mortensen Li Juel , Holt Rune , Knudsen Nadia Krarup , Nielsen John Erik , Juul Anders , Jorgensen Anne , Jensen Martin Blomberg

Currently, no treatment options exist to improve semen quality for the majority of infertile men. Proper interaction between germ and Sertoli cells in the testis is critical for sperm production, and a recent study suggested that Denosumab, an inhibitor of RANKL signaling, may stimulate sperm production in some infertile men. Here, we show in animal and human studies how expression of the RANKL signaling system is critical for both Sertoli cell function and the testicular resp...

ea0032oc2.2 | Bone &amp; Calcium | ECE2013

Influence of vitamin D and calcium on reproductive hormones: a study in a VDR-ablated male mouse model and 300 healthy men

Jensen Martin Blomberg , Lieben Liesbet , Nielsen John E , Willems Ariane , Juul Anders , Jorgensen Niels , Toppari Jorma , Carmeliet Geert , Rajpert-De Meyts Ewa

Introduction: Vitamin D (VD) is metabolized locally in the testis, and ablation of the VD receptor (Vdr−/−) in mice has proven a valid model for hereditary VD resistant rickets. However, only one of three published Vdr−/− strains presented with male infertility. Here, we investigated reproductive hormones, gene expression and the testicular histological phenotype of male Vdr−/−mice,...

ea0063p431 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Residual adrenocortical function in autoimmune addison’s disease: interim results of a cross-sectional study

Saevik AEse Bjorvatn , AEkermann Anna-Karin , Methlie Paal , Gunnar Nedrebo Bjorn , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Holte Synnove Emblem , Debowska Aleksandra , Sollid Stina Therese , Jorgensen Anders , Nermone Ingrid , Gronning Kaja , Finnes Trine , Grimnes Guri , Hoybye Charlotte , Skov Jakob , Dahlqvist Per , Wahlberg Jeanette , Isaksson Magnus , Quinkler Marcus , Bensing Sophie , Oksnes Marianne , Husebye Eystein

Background: Current dogma states that in autoimmune Addison’s disease (AAD), all adrenocortical function eventually is lost. Yet growing evidence suggests that a subgroup of patients retain some self-production.Aim: To explore whether residual production of adrenocortical steroids is present in a subgroup of AAD patients.Material and methods: In an open non-randomized cross-sectional study, an interim of 22 AAD patients delive...