Abstract Search

ea0049ep654 | Obesity | ECE2017

Growth hormone signaling and action in obese versus lean human subjects: evidence of increased hepatic GH sensitivity in obesity

Pedersen Morten Hogild , Bak Ann Mosegaard , Pedersen Steen Bonlokke , Jessen Niels , Moller Niels , Jorgensen Jens O.L.

Context: Obesity is accompanied by blunted GH secretion but relatively normal serum IGF-I levels, which suggests increased GH sensitivity. This, however, remains to be tested at the level of GH signaling in human subjects.Objective: To compare the effects of an acute intravenous GH bolus in obese vs normal weight subjects on GH signaling pathways in adipose and muscle tissue, substrate metabolism and insulin sensitivity.Subjects an...

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ea0020p462 | Obesity and Metabolism | ECE2009

Impact of growth hormone receptor blockade on substrate metabolism during short-term fasting in healthy subjects

Moller Louise , Norrelund Helene , Frystyk Jan , Moller Niels , Jorgensen Jens OL

Context and objective: During fasting growth hormone (GH) promotes lipolysis, attenuates glucose oxidation and preserves protein. Previous studies have primarily been conducted in GH deficient patients or during somatostatin-suppression of GH secretion. We aimed to study the impact of the fasting associated increase in GH without concomitant changes in other hormones, by the means of GH receptor (GHR) blockade.Design: Ten healthy young men participated i...

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Endocrine Abstracts

Growth hormone signaling and action in obese versus lean human subjects: evidence of increased hepatic GH sensitivity in obesity

Impact of growth hormone receptor blockade on substrate metabolism during short-term fasting in healthy subjects

BiosciAbstracts