Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp136 | Obesity | ECE2019

Administration of a growth hormone bolus down-regulates gene-expression of the g0/g1 switch gene 2 (g0s2) in subcutaneous adipose tissue in healthy, obese men: a randomized, placebo-controlled, cross-over study

Hjelholt Astrid , Jessen Niels , Arlien-Soborg Mai Christiansen , Pedersen Steen Bonlokke , Jorgensen Jenso Otto Lunde

Background: Growth hormone (GH) potently stimulates lipolysis, and after GH exposure, levels of serum free fatty acids (FFAs) increase in a distinct temporal pattern characterized by a 1-hour lag phase and a peak after 3 hours followed by a gradual return to baseline. This effect predominantly operates during fasting and promotes utilization of lipids from adipose tissue (AT) at the expense of glucose and protein. Prolonged fasting also downregulates the expression of the G0/G...