Searchable abstracts of presentations at key conferences in endocrinology

ea0041oc9.4 | Endocrine Tumours | ECE2016

The truncated somatostatin receptor sst5TMD4 is overexpressed in prostate cancer, where it increases aggressiveness features by regulating key tumor suppressors and oncogenes.

Hormaechea-Agulla Daniel , Manuel Jimenez-Vacas Juan , Ibanez-Costa Alejandro , Gomez-Gomez Enrique , Carrasco-Valiente Julia , Valero Rosa Jose , Moreno Maria M , Culler Michael D , Gahete Manuel D , Jose Requena Maria , Castano Justo P , Luque Raul M

Somatostatin is a pleiotropic neuropeptide that governs multiple biological targets, including tumor cell function, through a family of G protein-coupled receptors with 7-transmembrane domains (TMD), named sst1-5. However, we recently discovered sst5TMD4, an aberrantly spliced, truncated (only 4-TMDs) sst5-variant displaying unique molecular/functional features. sst5TM4 is overexpressed in various endocrine-related tumors exacerbating their malignant characteristics. Here, we ...