Searchable abstracts of presentations at key conferences in endocrinology

ea0094p322 | Bone and Calcium | SFEBES2023

Osteoporosis in a young male patient

Tsoutsouki Jovanna , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 58 year-old man presented with backache and was found to have T10-T12 vertebral fractures on spinal-MRI. He was diagnosed with osteoporosis on a DEXA-scan (lumbar-spine T-score-2.6) and was treated with Alendronate and Cholecalciferol at a neighboring hospital. He was referred to the endocrine bone-clinic for a second opinion regarding his osteoporosis. He had a history of multiple small bone fractures and Brucellosis that required a 2-month bed-rest. His family history incl...

ea0091cb58 | Additional Cases | SFEEU2023

Hypercalcaemia in a young female patient

Tsoutsouki Jovanna , North Matthew , Tebbs Daniel , Tharakan Goerge , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 35 year old lady presented with a one week history of back pain, myalgia, fatigue, epigastric pain, and persistent vomiting. She reported a four week history of reduced appetite and 4 kg weight loss. She had recently recovered from an uncomplicated COVID-19 infection. Past medical history included a previous eating disorder (anorexia and bulimia), and subsequent chronic gastritis. Drug history included Omeprazole 20 mg daily, Laxido 2 sachets daily and antacids (Rennies 4-8 ...

ea0094p267 | Reproductive Endocrinology | SFEBES2023

Kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Chia Eng Pei , Patel Bijal , Modi Manish , Young Megan , Papadopoulou Deborah , R Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....

ea0099p551 | Reproductive and Developmental Endocrinology | ECE2024

Endocrine responses to kisspeptin in an unusual case of kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Patel Bijal , Mills Edouard , Young Megan , Yeung Arthur , Koysombat Kanyada , Modi Manish , Papadopoulou Deborah , Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare condition characterised by congenital hypogonadotropic hypogonadism (CHH), usually due to defective migration of olfactory axons and GnRH-neurons. KS is typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilaterally hypoplastic or absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Kisspeptin is a potent stimulator of hypothalamic GnRH-neurons, and endocri...

ea0099p142 | Reproductive and Developmental Endocrinology | ECE2024

Decoding desire: a neurofunctional exploration of distressing low sexual desire reveals sexually dimorphic brain responses

Tsoutsouki Jovanna , Ertl Natalie , G Mills Edouard , B Wall Matt , Thurston Layla , Yang Lisa , Hunjan Tia , Phylactou Maria , Bassett Paul , Patel Bijal , Howard Jonathan , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Background: Distressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects 10% of women and 8% of men. The established ‘top-down’ neurofunctional model of HSDD in women suggests that in response to erotic cues, excessive activation of higher-level cognitive brain regions (involved in introspection/self-monitoring) suppresses lower-level sexual brain centres, thereby impeding normal sexual function. By contrast, the neurodysfunction in men wit...

ea00100oc1 | Oral Communications | SFEEU2024

Making scents of hemi-anosmia in a woman presenting with secondary amenorrhoea

Tsoutsouki Jovanna , Comninos Alexander N , Phylactou Maria , Young Megan , Mills Edouard , Maria Newman Anastasia , Wynn Nyunt Sandhi , Koysombat Kanyada , Yeung Arthur , Patel Bijal , Howard Sasha , S Dhillo Waljit , Abbara Ali

Case history: A 25-year-old woman presented with secondary amenorrhoea present since aged 18yrs. She had spontaneous albeit late menarche aged 16yrs and five menstrual periods over the subsequent two-years, before complete menstrual cessation. She denied other medical history, psychological stress, excessive exercise, or regular medications. Notably, she reported normal sense of smell via her right nostril, but anosmia via her left nostril. Family history included a diagnosis ...

ea00100p21 | Poster Presentations | SFEEU2024

Reversal of congenital hypogonadotrophic hypogonadism (CHH) in a woman with a heterozygous inactivating variant in GnRHR gene

W Nyunt Sandhi , Phylactou Maria , Koysombat Kanyada , Tsoutsouki Jovanna , C Yeung Arthur , Young Megan , Newman Anastasia , N Comninos Alexander , Mamoojee Yaasir , Pitteloud Nelly , Quinton Richard , S Dhillo Waljit , Abbara Ali

Case history: Our patient presented with primary amenorrhoea and incomplete puberty aged 15 yrs. Based on BMI >40 kg/m2 from early adolescence, clinical hyperandrogenism, family history of polycystic ovary syndrome (PCOS), and insulin resistance, she was diagnosed with PCOS and commenced on a combined oral contraceptive (COC), achieving breast development. Aged 21yrs, she was reassessed for amenorrhoea of COC. Biochemical assessment revealed hypogonadotrophic hy...

ea0099oc1.4 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Kisspeptin as a test of hypothalamic function in women presenting with oligo / amenorrhoea

Patel Bijal , Abbara Ali , Yeung Arthur , Phylactou Maria , Tsoutsouki Jovanna , Koysombat Kanyada , Young Megan , Nyunt Sandhi , Qayum Ambreen , Patel Aaran , Zielinska Agata , Omar Yusra , Eng Pei , Mills Edouard G , Hanassab Simon , Webber Lisa , Jayasena Channa , Tan Tricia , Quinton Richard , Clarke Sophie , Comninos Alexander , Dhillo Waljit

Background: Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhoea (FHA) are the two commonest causes of menstrual disturbance in pre-menopausal women. In practice, differentiating these two common reproductive disorders can be challenging. A fundamental abnormality that underpins both conditions is altered gonadotrophin releasing hormone (GnRH) pulsatility, being increased in PCOS but reduced in FHA. Likewise, congenital (e.g. congenital hypogonadotropic hyp...

ea0099oc9.4 | Oral Communications 9: Pituitary and Neuroendocrinology | Part II | ECE2024

Kisspeptin administration does not alter anxiety or circulating cortisol levels in humans

Mills Edouard G , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Clarke Sophie A. , Shah Amar J. , Izzi-Engbeaya Chioma , Tsoutsouki Jovanna , Bech Paul , Ertl Natalie , Demetriou Lysia , Wall Matthew B. , Goldmeier David , Abbara Ali , Comninos Alexander N. , Dhillo Waljit S.

Background: The neuropeptide kisspeptin is a key endogenous activator of the reproductive system. Due to its crucial role in modulating reproductive and behavioural processes, there has been accelerating interest in targeting kisspeptin-pathways to treat reproductive and psychosexual disorders. However, contradictory pre-clinical data from animal models suggests that kisspeptin can have an anxiolytic, anxiogenic or have no effects on anxiety. Given the rapid development of kis...