Searchable abstracts of presentations at key conferences in endocrinology

ea0073yi6 | Young Investigator Awards | ECE2021

Unveiling the pathophysiological relationship between prostate cancer and obesity: miR-107 as a novel personalized diagnostic and therapeutic tool

Prudencio Sáez-Martínez , Vicente Herrero-Aguayo , Juan M. Jiménez-Vacas , Trinidad Moreno-Montilla , Julia Carrasco-Valiente , André Sarmento-Cabral , José López-Miranda , Enrique Gómez-Gómez , Manuel D. Gahete , Raúl M. Luque

Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Therefore, more specific and non-invasive diagnostic biomarkers as well as novel therapeutic targets are urgently needed. As miRNAs have been proposed as promising elements for the identification of novel diagnostic and therapeutic tools for different pathologies, including cancer, we investigated the miRNA landscape in PCa and explored their putative diagnostic/therapeutic utilit...

ea0073aep384 | Endocrine-Related Cancer | ECE2021

Oncogenic role of splicing factor SRSF2/SC35 in pancreatic and prostate adenocarcinomas

Berbel Inmaculada , Alors-Perez Emilia , Juan M Jiménez-Vacas , Ricardo Blázquez-Encinas , Cristina Viyuela-García , Álvaro Arjona-Sanchez , Juan Manuel Sánchez-Hidalgo , Marina Sánchez-Frías , Enrique Gómez-Gómez , Ortiz Manuel Gahete , Alejandro Ibañez Costa , Luque Raul M. , Justo P. Castaño

IntroductionAlternative splicing allows the generation of multiple RNA isoforms from a single pre-RNA molecule, and thereby contributes to a multitude of physiological processes, but can also be involved in many diseases, including cancer. Indeed, disruption of alternative splicing has been linked to key cancer features, such as tumor growth, metastasis and hormone responsiveness and is increasingly regarded as a novel and transversal cancer hallmark. Th...

ea0073aep397 | Endocrine-Related Cancer | ECE2021

Anticancer activity of hydroxytyrosol and five semisynthetic lipophilic derivatives in prostate cancer cells

Antonio J. León-González , Prudencio Sáez-Martínez , Juan M. Jiménez-Vacas , Herrero-Aguayo Vicente , Antonio J. Montero-Hidalgo , Enrique Gómez-Gómez , Andrés Madrona , Justo P. Castaño , José L. Espartero , Gahete Manuel D. , Raúl M. Luque

Prostate cancer (PCa) is the second most diagnosed cancer type and the sixth cause of cancer death among men worldwide. Due to the usual slow course of the progression of this disease, there is a growing interest in finding chemopreventive therapeutics with a low risk of side effects. In line with this, recent studies have shown that hydroxytyrosol (HT), one of the main extra virgin olive oil phenolic compounds, exerts a protective role against different cancer types. Moreover...