Searchable abstracts of presentations at key conferences in endocrinology

ea0026s17.2 | Pituitary update | ECE2011

Update on pituitary surgery 2011

Honegger Juergen

The transsphenoidal surgical technique has dominated ever since Jules Hardy introduced microsurgery with the use of an operation microscope in the 1960s. Since the 1990s, endoscopic techniques have alternatively been applied in transsphenoidal surgery. Both microscopy and endoscopy should be accepted as established techniques which can often be used in a complementary fashion. It must be understood that microsurgery and endoscopy differ only in that they use different optical ...

ea0022p649 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Aftercare in patients with Cushing's disease and acromegaly: is there room for improvement?

Honegger Juergen , Milian Monika , Psaras Tsambika

Objective: Evaluation of aftercare, medical therapy and remission rate in Cushing’s disease (CD) and acromegaly (AC).Methods: Of 58 CD and 83 AC patients operated over 10 years were carefully evaluated. The patients received a disease-related questionnaire and were invited for a follow-up at the outpatient clinic of the Department of Neurosurgery. 33 CD and 52 AC patients returned the questionnaire, 25 CD and 37 AC patients participated personally. ...

ea0022p650 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Persistent hypocortisolism in Cushing's disease and persistent comorbidities in acromegaly determine neurocognitive function and quality of life after surgical treatment

Psaras Tsambika , Honegger Juergen , Milian Monika

Objective: Cushing’s disease (CD) and acromegaly (AC) are associated with psychological and psychiatric problems. Both pathologies cause a severe impairment in quality of life (QoL) that can persist even if biochemical remission and cure are achieved. The aim of the study was to investigate the influence of the current disease status (remission vs. no remission) on neurocognitive function and QoL in treated CD and AC patients. The second objective was to determine predict...

ea0022p651 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Demographic factors and the presence of comorbidities do not promote early detection of Cushing's disease and acromegaly

Psaras Tsambika , Milian Monika , Honegger Juergen

Objective: The aim of the study was to analyze the time-to-diagnosis interval in patients with Cushing’s disease (CD) and acromegaly (AC), to assess factors that promote early disease detection and to investigate the medical fields diagnosing the pathologies.Design: Case-record retrospective study.Patients: CD and 52 AC patients operated between June 1998 and December 2007.Measurements: All patients rece...

ea0022p646 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Growth modelling of non-functioning pituitary adenomas

Honegger Juergen , Zimmermann Sanna , Psaras Tsambika , Reincke Martin , Dietz Klaus

Objective: It is still unknown how pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. Definition of adenoma growth kinetics would substantially enhance knowledge of biological behaviour. The objective of this study was to define a growth model for non-functioning pituitary adenomas.Methods: Fifteen patients who had five or more serial high-quality examinations with magnetic resonance images or computerized tomo...

ea0056gp197 | Pituitary Basic | ECE2018

Efficacy of pharmacological USP8 inhibition in human Cushing’s disease tumours in vitro

Theodoropoulou Marily , Perez-Rivas Luis , Albani Adriana , Stalla Gunter , Buchfelder Michael , Flitsch Joerg , Honegger Juergen , Rachinger Walter , Reincke Martin

The tumorigenesis of Cushing’s disease is characterized by somatic mutations in the USP8 gene in almost half of the cases. USP8 encodes for ubiquitin specific protease 8, a deubiquitinase that rescues proteins involved in the regulation of ACTH synthesis in corticotroph cells. In the present study we tested the antisecretory and antiproliferative efficacy of a commercially available specific USP8 inhibitor (IC50 3.1 μM USP8; >90 μM USP7) in immortalized muri...