Searchable abstracts of presentations at key conferences in endocrinology

ea0015p364 | Thyroid | SFEBES2008

Hypothyroidism and hyponatraemia: diagnostic relevance of ADH measurement

Khan Azhar , Nair Sunil , Waldron Julian , Davies Marten , Heald Adrian

Background: Hyponatraemia is one of most common electrolyte abnormalities in acutely ill elderly patients. Severe hypothyroidism is often associated with hyponatraemia. The mechanism of hyponatraemia in hypothyroidism is not fully understood. It is suggested that hypothyroidism induces hyponatraemia either by inappropriate release of ADH or by decrease in GFR. Regardless of the mechanism, the net effect is impairment of water excretion. We report a case of severe hypothyroidis...

ea0015p6 | Bone | SFEBES2008

Sunlight deficiency: a reversible cause of low serum phosphate?

Chambers Thomas , Heald Adrian , Radford Daniela , Waldron Julian , Davies Marten , Baines Malcolm

Background: Vitamin D3 is generated in the skin of humans from 7-dehydrocholesterol by ultraviolet light. Vitamin D3 is hydroxylated to its metabolically active form in the liver and kidneys. The hydroxylated form of Vitamin D3, is required for both phosphate and calcium absorption in the gut and reabsorption from the kidneys. Vitamin D deficiency is associated with a low circulating calcium and phosphate.Case report: A 5...

ea0015p321 | Steroids | SFEBES2008

Partial 21-hydroxylase deficiency: diagnostic role of urinary steroid profiling

Heald Adrian , Qureshi Zubair , Khan Azhar , Waldron Julian , Davies Marten , Taylor Norman , Kane John

Background: Virilising congenital adrenal hyperplasia (CAH) is the most common cause of genital ambiguity, and 90–95% of CAH cases are caused by 21-hydroxylase deficiency. Associated inefficient cortisol synthesis results in increased CRH and ACTH levels, leading to production of excess sex hormone precursors. These are further metabolized to active androgens and to a lesser extent oestrogens. We recently reported that one of these androgens, DHEA-S or its metabolites sig...

ea0015p252 | Pituitary | SFEBES2008

Adjustment for macroprolactin: an integral part of laboratory assessment of hyperprolactinaemia

Blantern Liz , Qureshi Zubair , Heald Adrian , Anderson Simon , Radford Daniela , Waldron Julian , Davies Marten , McCulloch Alan , Kane John

Background: In most people, prolactin circulates predominantly as a 23-kDa monomer, and a high-molecular-weight form which in the vast majority of cases consists of a complex of prolactin and an anti-prolactin IgG autoantibody, commonly referred to as macroprolactin. This cross-reacts with conventional laboratory assays for prolactin.Report: In a consecutive series of 218 patients with prolactin elevated to 400 μ/l or more in men (normal range &#880...