Endocrine Abstracts

Introduction: Resistin is a cysteine–rich adipokine that was originally described as a molecular link between obesity and insulin resistance. Our previous study showed higher serum resistin levels in patients with gestational diabetes mellitus (GDM) in comparison with healthy pregnant women however conflicting results have been reported by other authors. Therefore in the present study we investigated whether there were significant differences in resistin mRNA expression i...

The risk of type 2 diabetes mellitus (T2DM) development is related to BMI, therefore this disease mainly occurs among overweight (OW) and obese (OB) people. However lean (L) individuals may also suffer from T2DM. The evolution of T2DM is a multistep process and starts with insulin resistance (IR), which may evolve into pre-diabetic state i.e.: impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). In up to 70% of patients pre-diabetic state evolves into T2DM. ...

Introduction: The genome-wide association studies have recently expanded the number of genetic susceptibility loci for type 2 diabetes and obesity. Transcription factor 7-like 2 (TCF7L2) gene seems to be one of the most predictive identifiable factors promoting T2DM development. It has been suggested that TCF7L2 influences pancreatic β-cell function butthe effect of genetic variants of TCF7L2 on metabolic syndrome development is not well characterized among subje...

Background: The alterations in collagen synthesis and connective tissue structure that occur in Ehlers–Danlos syndrome translate to an increased risk of bone mass loss and development of osteopenia and osteoporosis, which may be evaluated with bone turnover biomarkers. Some subtypes of Ehlers–Danlos syndrome are associated with structural alterations in the extracellular matrix glycoprotein tenascin-X. The purpose of this study was to assess the relationship between ...

Background: Ehlers–Danlos syndrome is a group of genetic conditions characterized by alterations in connective tissue structure, which produces various symptoms. Some subtypes of this syndrome are associated with structural alterations of tenascin-X, an extracellular matrix glycoprotein encoded by the TNXB gene, which partially overlaps the CYP21A2 gene, which encodes adrenal 21-hydroxylase. The purpose of this study was to assess the relationship between tenascin-X level...