Endocrine Abstracts

Background and Aims: Obesity is a major risk factor for type 2 diabetes (T2D). Remission of diabetes can be achieved by dietary weight loss although the underlying molecular mechanism(s) are unknown. These beneficial effects could be related to decreasing hepatic fat delivery to the pancreas and eventually restoring β-cell function. We hypothesised that hepatic de novo lipogenesis (DNL) is the primary driver of pancreas “lipotoxicity” and the pr...

Background and aims: Understanding the mechanisms that lead to remission of type 2 diabetes (T2D) after weight loss is critical to develop novel therapies. We hypothesized that weight loss decreases hepatic de novo lipogenesis (DNL), a primary mechanism expected to modulate T2D remission.Methods: 24 mice (NONcNZO10/ltJ) at age 5-6 weeks were placed for 12 weeks on high sucrose diet (HSD: 60% sucrose/20% fat). After 12 weeks, 6 mice were placed on calorie...