Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc9.2 | Oral Communications 9: Endocrine-Related Cancer | ECE2021

Utility of In1-ghrelin as a novel non-invasive diagnostic and prognostic biomarker of prostate cancer in patients with PSA in the grey-zone

Montero-Hidalgo Antonio J. , Herrero-Aguayo Antonio J. , Enrique Gómez-Gómez , Guler Ipek , Justo P. Castaño , Sarmento-Cabral André , Gahete Ortiz Manuel , Luque Raul M , Jiménez Vacas Juan Manuel

Prostate cancer (PCa) is one of the leading causes of cancer deaths among men population worldwide. This tumour pathology is commonly diagnosed through the determination of serum PSA levels. However, the diagnostic capability of PSA dramatically drops when considering patients with PSA levels lower than 10 ng/ml, the so-called “grey-zone”1. Therefore, additional non-invasive diagnostic biomarkers are urgently needed to substitute/complement PSA. In this se...

ea0073aep382 | Endocrine-Related Cancer | ECE2021

Nutritional assessment and Ghrelin system as predictors of clinical evolution in gastro-enteropancreatic neuroendocrine neoplasms

Carlos Manuel Alzás Teomiro , Soraya León-Idougourram , María Dolores Alcántara-Laguna , Gahete Manuel D. , María José Molina-Puertas , Justo P. Castaño , Raúl M. Luque , María Ángeles Gálvez Moreno , Aura D. Herrera-Martínez

BackgroundPatients with neuroendocrine neoplasms (NENs) might present with malnutrition due to the tumor itself and/or its treatment. Poor nutritional status and weight loss can lead to poor outcomes, including decreased quality of life, increased complication rates and mortality. Ghrelin is an orexigenic hormone, which is implicated in appetite regulation, body weight, inflammation and immune cell activation. Its gastric secretion mainly depends on the ...

ea0073aep384 | Endocrine-Related Cancer | ECE2021

Oncogenic role of splicing factor SRSF2/SC35 in pancreatic and prostate adenocarcinomas

Berbel Inmaculada , Alors-Perez Emilia , Juan M Jiménez-Vacas , Ricardo Blázquez-Encinas , Cristina Viyuela-García , Álvaro Arjona-Sanchez , Juan Manuel Sánchez-Hidalgo , Marina Sánchez-Frías , Enrique Gómez-Gómez , Ortiz Manuel Gahete , Alejandro Ibañez Costa , Luque Raul M. , Justo P. Castaño

IntroductionAlternative splicing allows the generation of multiple RNA isoforms from a single pre-RNA molecule, and thereby contributes to a multitude of physiological processes, but can also be involved in many diseases, including cancer. Indeed, disruption of alternative splicing has been linked to key cancer features, such as tumor growth, metastasis and hormone responsiveness and is increasingly regarded as a novel and transversal cancer hallmark. Th...

ea0073aep397 | Endocrine-Related Cancer | ECE2021

Anticancer activity of hydroxytyrosol and five semisynthetic lipophilic derivatives in prostate cancer cells

Antonio J. León-González , Prudencio Sáez-Martínez , Juan M. Jiménez-Vacas , Herrero-Aguayo Vicente , Antonio J. Montero-Hidalgo , Enrique Gómez-Gómez , Andrés Madrona , Justo P. Castaño , José L. Espartero , Gahete Manuel D. , Raúl M. Luque

Prostate cancer (PCa) is the second most diagnosed cancer type and the sixth cause of cancer death among men worldwide. Due to the usual slow course of the progression of this disease, there is a growing interest in finding chemopreventive therapeutics with a low risk of side effects. In line with this, recent studies have shown that hydroxytyrosol (HT), one of the main extra virgin olive oil phenolic compounds, exerts a protective role against different cancer types. Moreover...

ea0073ep129 | Endocrine-Related Cancer | ECE2021

PRPF8 regulates FAK/AKT pathway and cytoskeleton remodeling through modulation of fibronectin 1 splicing in liver pathologies

Natalia Hermán-Sánchez , Juan L. López-Cánovas , Mercedes del Río-Moreno , Antonio C. Fuentes-Fayos , Marina E. Sánchez-Frias , Víctor Amado , Rubén Ciria , Javier Briceño , Manuel de la Mata , Justo P. Castaño , Manuel Rodríguez-Perálvarez , Raúl M. Luque , Manuel D. Gahete

Obesity is emerging as a prevalent cause of chronic liver damage, which can lead to the development of metabolic-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), or even hepatocellular carcinoma (HCC). Increasing evidence suggests a profound dysregulation of the splicing machinery (spliceosome and splicing factors) in these pathologies; however, the role of PRPF8, a pivotal spliceosome element, has not been described in chronic liver pathologies. Th...