Searchable abstracts of presentations at key conferences in endocrinology

ea0041s12.1 | Novel insights of disorders in pubertal timing | ECE2016

Pubertal timing is changing: possible role for genetic, epigenetic and environmental factors

Juul Anders

Puberty marks the transition period from childhood into adulthood with the attainment of adult reproductive capacity. Timing of puberty exhibit marked interindividual variation and depends on genetic and lifestyle factors. Onset of puberty has started earlier during the last 20 years, which cannot be attributed to genetic factors. Thus, lifestyle and environmental factors must be responsible for these worrying trends....

ea0026s11.2 | Genetics of male infertility | ECE2011

Clinical aspects of Klinefelter syndrome in childhood, adolescence and adulthood

Juul Anders

Klinefelter syndrome (KS) which affects 1–2- per 1000 males, is not only challenging for the patients and their families. Professionals, who manage KS patients need a much better scientific foundation for decision making in patient care. Surprisingly little research on how to manage boys, adolescents and men with KS has been carried out in comparison to management of other clinical problems like, e.g. Turner syndrome. One of the problems has been that management, which mu...

ea0063p318 | Reproductive Endocrinology 1 | ECE2019

Semen quality in uncontrolled acromegalic patients with hypogonadism

Andreassen Mikkel , Juul Anders , Feldt-Rasmussen Ulla , Jorgensen Niels

Objective: Growth hormone (GH) activity might be implicated in male reproductive function. One previous study has suggested significantly reduced semen quality in untreated acromegalic patients due to both reduced sperm counts and motility.Design and methods: A retrospective study comprising 10 uncontrolled hypogonadal acromegalic patients (median age 29y) who delivered semen for cryopreservation before initiation of testosterone therapy. Semen ...

ea0049gp150 | Male Reproduction and Endocrine Disruptors | ECE2017

Semen quality in patients with adult-onset hypogonadotropic hypogonadism

Andreassen Mikkel , Juul Anders , Feldt-Rasmussen Ulla , Jorgensen Niels

Introduction: Gonadotropins from the pituitary gland are essential for testosterone production and spermatogenesis. However, little is known about semen quality in patients with adult onset gonadotropin insufficiency.Aim: To investigate semen quality in men with adult onset hypogonadotropic hypogonadism requiring testosterone replacement therapy.Patients and method: A single center study comprising all hypogonadal men with pituitar...

ea0032p624 | Growth hormome IGF axis – basic | ECE2013

Association between a common GH receptor polymorphism (exon 3-deletion), pre- and postnatal growth, serum insulin-like growth factor 1 and reproductive function in 838 healthy young males

Andreassen Mikkel , Beck Jensen Rikke , Jorgensen Niels , Juul Anders

Introduction: A common genetic polymorphism in the GH receptor (GHR) is deletion of the entire exon 3 sequence (GHRd3 isoform). The GHRd3 isoform seems to be more sensitive with increased downstream GH signalling in activated exon 3 deleted receptor dimers (GHRd3/d3) compared to full length receptor dimers (GHRfl/fl). Presence of the GHRd3 isoform might be associated to pre- and postnatal growth and pubertal development in boys, although controversy exists. The aim was to inve...

ea0032p804 | Paediatric endocrinology | ECE2013

GH therapy and effect on ovarian function and morphology in short prepubertal SGA girls

Tinggaard Jeanette , Jensen Rikke Beck , Sundberg Karin , Juul Anders

Background: GH receptors are present in ovaries and GH may have a physiological role for ovarian function and development.Objective and hypothesis: The objective of this study was to examine pubertal development and ovarian growth and differentiation during GH therapy.Methods: Clinical characteristics, reproductive hormones and ultrasonographic examination of the internal genitals were determined in 18 prepubertal girls during 3 ye...

ea0090p36 | Calcium and Bone | ECE2023

No effects of high-dose vitamin D supplementation on white blood cell count, CRP and risk of upper respiratory tract infections in infertile men – Secondary analyses from a randomized clinical trial

Wall-Gremstrup Gustav , Holt Rune , Juul Anders , Joergensen Niels , Blomberg Jensen Martin

Background: vitamin D has been associated with different beneficial effects on the immune system. The vitamin D activating (CYP2R1 and CYP27B1) and inactivating (CYP24A1) enzymes, including the vitamin D receptor (VDR) are expressed in several types of white blood cells (WBC). A range of studies have explored whether vitamin D positively affects risk of and severity of respiratory tract infections such as tuberculosis, influenza, cold and COVID-19.Object...

ea0090p392 | Endocrine-related Cancer | ECE2023

Influence of CaSR in testicular germ cell tumors

Hjerresen Jasmin , Gobel Nielsen Gustav , Hjorth Andreassen Christine , Juul Anders , Blomberg Jensen Martin

More than 90% of malignant testicular tumors arise in the germ cells and are denoted testicular germ cell tumors (TGCTs). TGCTs are one of the most common cancers among men between 15 to 40 years of age and arise from a common precursor cell, the germ cell neoplasia in situ (GCNIS), an arrested and transformed fetal gonocyte that become invasive after puberty. TGCTs are divided into seminomas and nonseminomas based on histology. Fortunately, TGTCs are highly sensitive to cispl...

ea0037ep1235 | Clinical Cases–Pituitary/Adrenal | ECE2015

An unusual case of possible cyclic Cushing's disease in a young man with Klinefelter syndrome

Christoffersen Thea , Jarlov Anne Elisabeth , Juul Anders , Poulsgaard Lars , Rasmussen Aase Krogh , Feldt-Rasmussen Ulla

Introduction: Cyclic Cushing’s syndrome (CS) is a rare disorder, characterised by alternating periods of normo – and hypercortisolism.Case report: An 18-year-old young man was followed at the Department of Growth and Reproduction due to Klinefelter and received androgen replacement since the age of 12. As he was shifted to i.m. injections his liver enzymes increased and liver damage due to androgen replacement was suspected. A liver biopsy show...

ea0032p338 | Developmental Endocrinology | ECE2013

TurboFlow-LC-MS/MS method for quantification of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in children

Soeborg Tue , Frederiksen Hanne , Johannsen Trine Holm , Juul Anders , Andersson Anna-Maria

Diagnosis and management of infants and children with sex steroid disorders requires fast and simultaneous assessment of several sex steroid metabolites in serum at low concentrations and on small sample volumes. Therefore, we developed a sensitive and selective TurboFlow-LC-MS/MS method for quantification of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in serum from pre-pubertal children.Total run time was 10.75 mi...