Endocrine Abstracts

Introduction: Ectopic location of the parathyroid glands has been described in 10-15% of patients with hyperparathyroidism. Upper cervical localization is exceptional and may be missed by preoperative localization techniques. We report a rare case of parathyroid adenoma of the upper jugulo-carotid region.Observation: A 41-year-old woman with no notable pathological history presented diffuse osteoarticular pain. Physical examination showed a right superio...

Introduction: Primary hyperparathyroidism is associated with lithiasis, but this has been universally considered to refer to kidney lithiasis. Sialolithiasis as a comorbidity or result of primary hyperparathyroidism is uncommon. We report a rare case of submandibular lithiasis in a child and discuss the etiological assessment of this condition.Materials and Methods: We report a rare case of submandibular lithiasis in a child revealing primary hyperparath...

Introduction: Cortisone-induced osteoporosis (CO) is the most frequent complication of corticosteroid therapy. It is the first cause of secondary osteoporosis. The aim of this study is to clarify the characteristics of CO.Patients and Methods: We report a retrospective study of 39 cases of CO among 128 cases of osteoporosis during a 15-year period. The diagnosis of CO was based on a bone densitometry (BMD) of more than -1.5 standard deviations.<p cla...

The aim of this study is to report a case of an unusual presentation of anaplastic thyroid carcinoma and describe its clinical, radiological and management particularities. Observation: We report the case of a 60 year-old female patient who presented with a two-week history of progressive aphagia, associated with hemoptysis. She also described recent shortness of breath, and a painless cervical mass evolving for 10 months, rapidly enlarging during the last four weeks. Her medi...

Introduction: Hypoparathyroidism (HPTH) is an uncommon condition resulting in the production of insufficient amounts of parathyroid hormone (PTH) by the parathyroid glands consequently affecting the calcium phosphate balance. The most frequent etiology of HPTH is the damage to or removal of the parathyroid glands due to a surgery for another condition. Other causes, including autoimmunity and genetic disorders may be responsible for HPTH. Our aim is to compare the different cl...

Introduction: Addison disease is associated with high risk of fractures and low bone mineral density. Causes are complex, including supraphysiologic glucocorticoid replacement therapy and concomitant autoimmune disorders. The aim of our study is to assess the influence of glucorticoid replacement therapy on bone mineral density in patients with Addison disease.Patients and methods: Descriptive and analytical cross- sectional study including 50 patients w...

Introduction: Mitochondrial diabetes (DM) is a monogenic form of maternal transmission diabetes that is caused by mutations in the mitochondrial genome. These mutations affecting mitochondrial function may be the cause of initiation of the phenomenon of apoptosis itself having an aggravating role of the phenotype in patients with mitochondrial diabetes.Materials and Methods: This study involved 43 patients with mitochondrial diabetes (20 non-syndromic an...

Introduction: Because of a long-term glucocorticoid replacement over many years, patients with Addison disease may have an increased occurrence of osteoporosis. Furthermore, the prevalence of osteoporosis in patients with Addison disease may also be increased because of premature menopause associated autoimmune endocrinopathies and hypovitaminosis D.The objective of this study is to assess the incidence and risk factors for osteoporosis among patients with Addison disease....

Introduction: Even at physiological doses, glucocorticoid replacement therapy may lead to deleterious outcomes on bone mineral density (BMD).The aim of our study was to investigate the BMD in Tunisian patients with Addison disease and to identify the risk factors associated with its decline.Patients and methods: The study included 50 patients diagnosed with primary adrenal disease (Addison disease). BMD was assessed by the dual -energy -X-ray absopitomet...

Introduction: Hypoparathyroidism (HPT) is an often under-diagnosed condition. It is imperative to diagnose it at an early stage and to initiate prompt treatment given the evolving potential of the disease.The aim of our study is to describe the epidemiological, clinical and paraclinical features of HPT.Patients and Methods: This is a retrospective study of 61 observations of HPT collected at the endocrinology department during a 12-year period.<p cla...