Searchable abstracts of presentations at key conferences in endocrinology

ea0036oc7.5 | Oral Communications 7 | BSPED2014

The relationship of vibration perception threshold with metabolic control and duration of disease in British children with type 1 diabetes

Kallampallil Jins , Goodwin Simon , Riddle Miles

Introduction: Type 1 diabetes affects a large number of children and adolescents, and its incidence is on the rise worldwide. The most devastating and important consequence of diabetes is its role in the development of long-term microvascular complications. This study aimed to study the role of the non-invasive vibration perception threshold (VPT) test in detecting subclinical peripheral neuropathy, and its correlation with metabolic control and duration of disease in British ...

ea0036P74 | (1) | BSPED2014

Impaired insulin and IGF2 signalling in the primordial growth disorder 3-M syndrome

Kallampallil Jins , Acimovic Ksenija , Hanson Daniel , Whatmore Andrew , Clayton Peter

Introduction: 3-M syndrome is associated with mutations in CUL7, OBSL1 and CCDC8 with the three proteins interacting within a novel growth pathway. The impact of this pathway on cellular growth has not been fully defined. We have shown that i) GH and IGF1 signalling are altered; ii) IGF2 expression is reduced and iii) expression of insulin receptor isoforms are altered in 3-M fibroblasts.Aim: To characterise the activa...