Endocrine Abstracts

Background and aims: Understanding the mechanisms that lead to remission of type 2 diabetes (T2D) after weight loss is critical to develop novel therapies. We hypothesized that weight loss decreases hepatic de novo lipogenesis (DNL), a primary mechanism expected to modulate T2D remission.Methods: 24 mice (NONcNZO10/ltJ) at age 5-6 weeks were placed for 12 weeks on high sucrose diet (HSD: 60% sucrose/20% fat). After 12 weeks, 6 mice were placed on calorie...