Endocrine Abstracts

Neuroendocrine tumours are heterogenous group of diseases that can originate from any part of the gastrointestinal tract, bronchi, Thyroid and Pancreas. Tumours that arise from the endocrine Pancreas, on the islet of Pancreas, are called Pancreatic NET. Pancreatic NETs have an incidence of < 0.1 % per one million person and can lead to secretion of ectopic ACTH (1). Ectopic ACTH secretion accounts for 5-10 % of all patients presenting with ACTH dependent hypercortisolism: ...

A 59 year old female patient presented with fall and Syncopal episode to Emergency Department. She had a few days history of increasing thirst, polyuria and diffuse abdominal discomfort. These symptoms were ongoing for weeks prior to her syncopal episode. Her past medical history of Endometriosis, Type 2 diabetes mellitus, epilepsy, ex-IVDU user with hep B in remission and self-neglect. She suffered with frequent episodes of heart burns and self-treated this with over counter ...

Introduction: Hypothyroidism and hyperthyroidism are commonly encountered medical disorders that can be associated with neurologic and neuromuscular dysfunction. Muscle involvement is a common manifestation of both clinical and subclinical hypothyroidism, although this may not always be clinically appreciated. Hypothyroid associated myopathy can cause weakness, cramps, aching and painful muscles, sluggish movements and Severe myopathy secondary to hypothyroidism leading to Rha...

Here we present a 49 year-old-male patient with known T1DM, hypothyroidism on Levothyroxine, with previous history of poor compliance with his Levothyroxine. He was admitted with 3 days history of bilateral feet swelling and foot droop. Following the improvement of his leg swellings, his bilateral foot droop became more prominent. He was diagnosed with Hashimoto hypothyroidism with anti TPO ab levels of 279 IU/Ml (reference range: <34 IU/ml) in 2012. His regular medication...

Introduction: Milk – alkali syndrome is a rare and distinctive disorder caused by ingestion of large amounts of calcium and absorbable alkali resulting in hypercalcemia. It is characterized by a triad of hypercalcemia, metabolic alkalosis and renal failure. It was first described in 1920s, as it was mainly caused by administration of milk and bicarbonate for treatment of peptic ulcers. Since the usage of new treatment modalities for peptic ulcer disease, the incidences of...

Background: Iatrogenic adrenal insufficiency (AI) refers to primary, secondary, or tertiary hypoadrenalism associated with drug administration, surgery, or irradiation. The most common cause of secondary adrenal insufficiency is exogenous glucocorticoids. Hepatic metabolism of inhaled corticosteroids (ICS) takes place via cytochrome P450 3A4. Nevertheless, it can be decreased by enzyme inhibitors such as itraconazole or ritonavir, thus leading to an increase in the bioavailabi...

Background: Bruns Garlands syndrome is a rare disorder in people living with diabetes, manifesting as unilateral or bilateral muscle pain, weakness and atrophy in the proximal region of the lower limbs. Herein, we present the case of a patient with Bruns-Garland syndrome caused by sodium/glucose co-transporter 2 inhibitors (SGLT2i).Case description: A 55-year-old male with background of type 2 diabetes for 5 years, and currently on oral therapy, presente...

Background: Bruns Garlands syndrome is a rare disorder in people living with diabetes, manifesting as unilateral or bilateral muscle pain, weakness and atrophy in the proximal region of the lower limbs. Herein, we present the case of a patient with Bruns-Garland syndrome caused by sodium/glucose co-transporter 2 inhibitors (SGLT2i).Case description: A 55-year-old male with background of type 2 diabetes for 5 years, and currently on oral therapy, presente...

Background: Radioiodine therapy (I-131) is commonly prescribed for benign thyroid disease in keeping with recommended guidelines.Aims: To determine the effectiveness of I-131 in treating benign thyroid disease and the rates of hypothyroidism following treatment and by diagnosis.Methods: We identified 100 patients who received radioiodine therapy between November 2013 and June 2015 from a database held in the Medical Physics Departm...

Introduction: Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disease presenting with fever and lymphadenitis and mostly affecting adults younger than 40 years of age and of Asian descent. Its aetiology and pathogenesis are unknown though KFD often occurs in patients with concomitant autoimmune illness such as autoimmune thyroiditis or lupus erythematosus (SLE). We report a case of a patient with KFD and fluctuating thyroid function and thyroid autoantibody levels.</p...