Endocrine Abstracts

Liver dysfunction is common in patients with hyperthyroidism. The underlying mechanisms remain unclear. Predictors of liver dysfunction and recovery are controversial. The aim of this study was to assess the prevalence of elevated liver enzymes in patients with uncontrolled hyperthyroidism and to identify its predictive factors.Methods: This is a retrospective study conducted in 131 patients with hyperthyroidism admitted in the endocrinology department o...

Introduction: The insulin tolerance test (ITT) is the gold standard for hypothalamic–pituitary adrenal axis assessment. There are different protocols depending on the number and timing of serum samples. Our study aimed to investigate the kinetics of serum glucose and cortisol levels during ITT and to determine the most appropriate times for blood samples.Methods: Our study was cross-sectional and descriptive. One hundred patients with suspected adre...

Introduction: Vitamin D deficiency is an emerging concern that has the potential to impact one’s health, even in sunny Mediterranean countries like Tunisia. This issue is particularly notable among indoor workers in the healthcare sector, who experience minimal sun exposure. The aim of this study was to describe the Vitamin D profile within this specific population and to establish its association with lipid parameters.Methods: This cross-sectional ...

Introduction: Cushing’s syndrome (CS) has relevant morbidity and mortality and poses several diagnostic challenges underlining the need for a prompt diagnosis in order to initiate earlier treatment. The aim of the present study was to develop a new clinical and biological score to predict the diagnosis of CS.Methods: This was a monocentric retrospective study including patients who were admitted to the Department of Endocrinology of La Rabta Hospita...

Introduction: The insulin tolerance test (ITT) is the gold standard for hypothalamic-pituitray adrenal axis assessment. An adequate response of serum cortisol level above or equal to 18 μg/dl confirms the integrity of the adrenal axis. Otherwise, it confirms adrenal insufficiency (AI). The aim of our study was to investigate clinical and biological factors for the prediction of an adequate response during the ITT.Methods: We conducted a cross-sectio...

Introduction: The insulin tolerance test (ITT) is commonly used for the evaluation of the corticotropic axis. There are different protocols depending on the number and timing of blood samples. The aim of our study was to investigate the predictive factors of a late response during ITT.Methods: Our study was cross-sectional and descriptive. One hundred patients with suspected adrenal insufficiency (AI) were evaluated. An intravenous rapid insulin bolus of...