Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep527 | Diabetes complications | ECE2016

Detection of hypoglycemia in type 2 diabetic patients

Tsirona Sofia , Pappas Christos , Kandaraki Eleni , Kassi Georgia , Chronopoulou Genovefa , Diamanti-Kandarakis Evanthia

Introduction: Hypoglycemia consists a significant problem in insulin treated type 2 diabetic patients. The present study compared the incidence of hypoglycemic episodes in type 2 diabetics between continuous glucose monitoring/CGM vs self monitoring of blood glucose/SMBG.Methods: Seventeen patients with type 2 diabetes underwent a 24 h CGM for a period of 3–5 consecutive days. At the same period they recorded their glucose values using SMBG from fou...

ea0037ep18 | Adrenal cortex | ECE2015

Subclinical Cushing's syndrome and clinical implications in bilateral compared to unilateral adrenal incidentalomas: a meta-analysis

Paschou Stavroula A , Kandaraki Eleni , Dimitropoulou Fotini , Goulis Dimitrios G , Vryonidou Andromachi

Introduction: The aim of this study was to systematically review the literature for studies that have investigated possible differences in prevalence of subclinical Cushing’s syndrome (SCS) and related clinical implications between patients with unilateral (UAI) and bilateral adrenal incidentalomas (BAI) and to meta-analyze the best evidence available.Methods: Electronic databases PubMed, MEDLINE and EMBASE were systematically searched. Main study o...

ea0035p641 | Female reproduction | ECE2014

Relationship between visceral adiposity index, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with polycystic ovary syndrome

Androulakis Ioannis , Kandaraki Eleni , Christakou Charikleia , Karachalios Athansios , Marinakis Evangelos , Paterakis Thomas , Diamanti-Kandarakis Evanthia

Objective: The clinical phenotype of PCOS includes reproductive and hormonal aberrations. Visceral adiposity index (VAI) is an indicator which could connect hyperandrogenism and anovulation. The objective was to evaluate the relationship between VAI, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with PCOS.Patients: 180 women with PCOS diagnosed with Rotterdam criteria.Measurements: We correlated V...

ea0070ep126 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Augmentation index in the assessment of pulse wave reflection assessment in lean and obese women with polycystic ovary syndrome (PCOS)

Alexandraki Krystallenia , Kandaraki Eleni , Papaioannou Theodoros , Piperi Christina , Argyris Antonis , Papamichael Christos , Protogerou Athnasios , Lekakis John

Objective: Conflicting findings have been published regarding the pressure wave reflection and the arterial stiffness in young women with PCOS as opposed to the overt ab initio presence of endothelial dysfunction compared with controls which can be reversed six months after metformin administration. The aim of this study was to investigate arterial stiffness and wave reflections in young women with polycystic ovary syndrome (PCOS) with respects to the different weight...

ea0032p411 | Diabetes | ECE2013

Advanced glycation end-products inhibit insulin signaling in human granulosa cells

Piperi Christina , Papageorgiou Efstathia , Kandaraki Eleni , Koutsilieris Michael , Diamanti-Kandarakis Evanthia

Introduction: AGEs have been shown to be accumulated in granulosa cell layer from human ovaries in normal and in women with polycystic ovarian syndrome (PCOS) and insulin resistance. AGEs interfere with insulin signaling pathways of several target tissues and are implicated in insulin resistance mechanisms. There is evidence that within the ovary these pathways are also important for glucose metabolism and normal folliculogenesis. The effect of human glycated albumin (HGA) eit...

ea0016p254 | Diabetes and cardiovascular diseases | ECE2008

Increased serum AGEs is a distinct finding in lean women with PCOS

Diamanti-Kandarakis Evanthia , Katsikis Ilias , Piperi Christina , Kandaraki Eleni , Piouka Athanasia , Papavassiliou Athanasios , Panidis Dimitrios

In insulin resistant, young women with PCOS elevated serum AGEs and their receptor RAGE have been reported. The present study (approved by the local ethical committee) was undertaken to determine whether increased levels of serum AGEs in PCOS is a distinct finding compared with age- and BMI-matched women, presenting the isolated components of the syndrome and whether serum AGE levels were different among PCOS phenotypes. A total of 193 lean non-insulin resistant women were stu...

ea0016p649 | Reproduction | ECE2008

Accumulation of dietary glycotoxins in the reproductive system of normal female rats

Diamanti-Kandarakis Evanthia , Piperi Christina , Kandaraki Eleni , Korkolopoulou Penelope , Patsouris Efstratios , Papalois Apostolos , Papavassiliou Athanasios

The present study aimed to investigate whether dietary advanced glycation end-products (AGEs) are detected in the ovarian tissue of normal female rats and whether they affect metabolic or hormonal profile.Normal rats were randomly assigned to regular diet, high (H-AGE) or low (L-AGE) content for 6 months. Age-matched rats fed with regular diet served as controls.H-AGE rats, demonstrated higher levels of fasting glucose (P&#6...

ea0056gp19 | Adrenal Case reports | ECE2018

Nonclassical congenital adrenal hyperplasia in a young patient with Type 1a Glycogen storage disease: is there a novel link between glucose metabolism and adrenal steroidogenesis?

Kandaraki Eleni , Papalou Olga , Spyridon Dourakis , Konstantoulakis Pantelis , Diamanti-Kandarakis Evanthia

Introduction: Glycogen storage disease type Ia is a rare genetic disorder that develops due to deficient activity of the enzyme glucose 6-phosphatase and manifests clinically early in life with hypoglycemia and failure to thrive, as well as with organ dysfunction, due to excess glycogen accumulation, including hepatomegaly and kidney dysfunction. Endocrine manifestations are commonly encountered in these patients. However, due to their rarity, endocrine dysfunction has not bee...

ea0056p137 | Endocrine tumours and neoplasia | ECE2018

Unraveling the incidence and clinical patterns of neuroendocrine neoplasms in Greece, through the experience of multipotent, specialized clinical centers.

Papalou Olga , Kandaraki Eleni , Papadakis Georgios , Nikou Georgios , Diamanti-Kandarakis Evanthia

Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from neuroendocrine cells in the endocrine and central nervous system, the natural history of which remains inadequately understood. Large epidemiological studies are gradually emerging from different countries worldwide, which contribute to the establishment of a spherical view about these tumors. The purpose of this study is to evaluate the epidemiological, clinical and pathological cha...

ea0056ep145 | Reproductive Endocrinology | ECE2018

The combination of cardiovascular risk factors in PCOS and the risk for cardiovascular disease events

Papadakis Georgios , Kandaraki Eleni , Papalou Olga , Vryonidou Andromachi , Diamanti-Kandarakis Evanthia

Objectives: • PCOS is defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders.• Women are exposed to increased risk for cardiovascular disease, hypertension, type 2 diabetes mellitus and other metabolic complications• Cardiovascular disease (CVD) is one of the most common cause of mortality wor...