Searchable abstracts of presentations at key conferences in endocrinology

ea0015p242 | Pituitary | SFEBES2008

Macroprolactin: role of serial measurement through pregnancy

Nair Sunil , Blantern Liz , Radford Daniela , Davies Marten , Kane John , Heald Adrian

Background: Recent studies have indicated that macroprolactinaemia accounts for up to 26% of biochemical hyperprolactinaemia depending on the assay in use. Delayed metabolic clearance of macroprolactin together with detection by most automated prolactin immunoassay systems leads to pseudo-hyperprolactinemia in patients harbouring this form of complexed prolactin.We here describe the use of serial macroprolactin measurement to assist in the management of ...

ea0015p321 | Steroids | SFEBES2008

Partial 21-hydroxylase deficiency: diagnostic role of urinary steroid profiling

Heald Adrian , Qureshi Zubair , Khan Azhar , Waldron Julian , Davies Marten , Taylor Norman , Kane John

Background: Virilising congenital adrenal hyperplasia (CAH) is the most common cause of genital ambiguity, and 90–95% of CAH cases are caused by 21-hydroxylase deficiency. Associated inefficient cortisol synthesis results in increased CRH and ACTH levels, leading to production of excess sex hormone precursors. These are further metabolized to active androgens and to a lesser extent oestrogens. We recently reported that one of these androgens, DHEA-S or its metabolites sig...

ea0015p252 | Pituitary | SFEBES2008

Adjustment for macroprolactin: an integral part of laboratory assessment of hyperprolactinaemia

Blantern Liz , Qureshi Zubair , Heald Adrian , Anderson Simon , Radford Daniela , Waldron Julian , Davies Marten , McCulloch Alan , Kane John

Background: In most people, prolactin circulates predominantly as a 23-kDa monomer, and a high-molecular-weight form which in the vast majority of cases consists of a complex of prolactin and an anti-prolactin IgG autoantibody, commonly referred to as macroprolactin. This cross-reacts with conventional laboratory assays for prolactin.Report: In a consecutive series of 218 patients with prolactin elevated to 400 μ/l or more in men (normal range &#880...