ea0005oc33 | Thyroid and Calcium | BES2003
O'Shea P
, Harvey C
, Suzuki H
, Kaneshige M
, Kaneshige K
, #S-y|#Cheng|#
, Williams G
Thyroid hormone (T3) is essential for skeletal development and maintenance of bone mineralisation. T3 actions are mediated by two receptors, TRalpha and TRbeta. Mutations in TRbeta cause autosomal dominant resistance to thyroid hormone (RTH) due to dominant negative activity of the mutant receptor. Short stature and abnormal skeletal development are prominent features of RTH, whereas TRalpha mutations have not been described and are postulated to result in no phenotype or to b...