Searchable abstracts of presentations at key conferences in endocrinology

ea0031p339 | Steroids | SFEBES2013

Spot urine cortisol: creatinine ratio: a useful screening test for patients with Cushing's syndrome

Paul Thomas , Kapoor Nitin , Job Victoria , Lakshmanan Jeyaseelan , Rajaratnam Simon

Introduction: Cushing’s syndrome(CS) is associated with high morbidity and mortality which warrants a good screening test that is less laborious. We explored the possibility of using urine spot cortisol:creatinine ratio (UCCR) as a new screening test for Cushing’s syndrome.Aims and objectives: To study the efficacy of UCCR as a screening test for patients with Cushing’s syndrome.To compare UCCR in patients with CS, o...

ea0034p27 | Bone | SFEBES2014

The diagnosis of osteoporosis among South Indian male and female subjects with low impact hip fracture and comparison between Indian Council of Medical Research and Caucasian Bone Mineral Density Databases

Thomas Nihal , Shetty Sahana , Kapoor Nitin , Asha H S , Naik Dukhabandhu , Visalakshi P , Paul Thomas

Aims and objectives: This study was undertaken to look at the agreement between the hologic database (HD) based on NHANES bone mineral density (BMD) data in Caucasians and the ICMR database (ICMRD) published in 2010 in defining normal and subnormal BMD in subjects with or without hip fracture and to arrive at a BMD cut off which has a high sensitivity of predicting fracture.Materials and methods: A cross sectional study of 3098 subjects (men-341 and wome...

ea0044p49 | Bone and Calcium | SFEBES2016

The impact of primary hyperparathyroidism and its treatment on bone mineral density, bone mineral parameters, insulin resistance, body composition and quality of life – A prospective pilot study from India

Paul Thomas V , Shetty Shrinath , Kapoor Nitin , Shetty Sahana , Paul M J , Abraham Deepak , Ramakant Pooja , Dian Joseph , Thomas Nihal

Aims: To study changes in bone mineral density (BMD), bone mineral parameters, metabolic profile, body composition and quality of life at base line and 6 months following parathyroidectomy, in subjects with primary hyperparathyroidism (PHPT).Material and methods: This prospective study was conducted over 18 months with first 12 months of recruitment and next 6 months for follow-up. Sixty-eight patients with PHPT who underwent surgery were compared with 1...

ea0044p50 | Bone and Calcium | SFEBES2016

Impact of hepatitis B-related chronic liver disease and its therapy on bone health

Paul Thomas V , Kapoor Nitin , Gangadharan Sajith Kattiparambil , Shetty Sahana , Goel Ashish , Zachariah Uday , Eapen Chundamannil E

Objective: To study the impact of HBV related chronic liver disease (CLD) and its treatment with Tenofovir on bone health in Indian subjects.Methods: This cross-sectional study included men between 18 and 60 years and comprised of three groups: Group 1 was treatment naïve HBV-related CLD (n=79), Group 2 – those with HBV-related CLD on tenofovir for at least 1 year duration (n=136), Group 3 – normal age, sex and BMI-matche...

ea0090p139 | Pituitary and Neuroendocrinology | ECE2023

Patients with acromegaly continue to derive clinical benefit from pasireotide long-acting release (LAR) for up to 12 years of treatment: Follow-up analysis of patients who received pasireotide during the clinical trial programme

Gadelha Monica , Grineva Elena , Miguel Escalante Pulido Jesus , Rollin Guilherme , Leelawattana Rattana , De Block Christophe , Piacentini Andrea , Schmidt Fabian , Pedroncelli Alberto M , Kapoor Nitin

Introduction: Acromegaly is associated with significant morbidity and reduced quality of life. A robust clinical programme (14 trials) established pasireotide as an effective second-generation somatostatin receptor ligand for the treatment of various endocrine conditions, including acromegaly. Patients who completed a previous pasireotide trial and continued to receive clinical benefit, according to the parent study investigator, could continue treatment in the B2412 rollover ...

ea0090p682 | Pituitary and Neuroendocrinology | ECE2023

A rollover study for patients who continued to receive benefit from pasireotide at completion of an earlier trial (B2412): An 8-year interim analysis

Gadelha Monica , Bronstein Marcello , Grineva Elena , Kapoor Nitin , De Block Christophe , Miguel Escalante Pulido Jesus , Rollin Guilherme , Baggenstoss Rejane , Piacentini Andrea , Pedroncelli Alberto , Gallardo Wilson

Introduction: A robust clinical programme of 14 trials demonstrated pasireotide as an effective treatment for patients with rare endocrine disorders, including acromegaly and Cushing’s disease (CD). Patients with acromegaly or CD have significant morbidity, reduced quality of life and, if inadequately treated, higher mortality risk than the general population. This 8-year interim analysis evaluated long-term safety of pasireotide treatment in patients with acromegaly, CD ...

ea0028p42 | Clinical practice/governance and case reports | SFEBES2012

Endoscopic ultrasonography is a sensitive tool in the preoperative localization of insulinoma

Joseph A , Kapoor Nitin , Asha H , Simon Ebby , Chacko Ashok , Thomas Elsa , Eapen Anu , Ramakrishna Banumathi , Abraham Deepak , Paul M , Paul Thomas , Thomas Nihal , Rajaratnam Simon

Introduction: Various imaging modalities are used in the preoperative localization of insulinoma. CT is the modality that is in widespread use. Endoscopic ultrasound (EUS) allows the transducer to be placed in close proximity to the pancreas, thereby yielding images of higher quality, leading to accurate localization. An accurate preoperative localization results in a minimal invasive surgery and less occurrence of residual tumors, translating into a better clinical outcome. O...

ea0038p77 | Clinical practice/governance and case reports | SFEBES2015

Phaeochromocytoma: experience from a single centre in South India

Naik Dukhabandhu , Das Gupta Riddhi , Asha H S , Paul Thomas V , Kapoor Nitin , Mahesh D M , Cherian Anish Jacob , Abraham Deepak T , Shanthly Nylla , Oomen Reji , Chandramohan Anuradha , Ramakrishna Banumathi , Pai Rekha , Paul M J , Rajaratnam Simon , Thomas Nihal

Phaeochromocytoma (PCC) and paragangliomas (PGL) are neuroendocrine tumours derived from the embryonic neural crest, located either within the adrenal gland or at extra-adrenal sites.Objective: To study the clinical, biochemical, imaging characteristics, and mutational profile of patients with PCC/PGL treated at our institution.Methods: We collected data of patients with PCC/PGLs managed at Christian Medical College, Vellore, India...

ea0038p101 | Clinical practice/governance and case reports | SFEBES2015

A complex case of MEN1

Naik Dukhabandhu , Mahesh D M , Asha H S , Abraham Deepak T , Shanthly Nylla , Chandramohan Anuradha , Burad Deepak , Ramakrishna Banumathi , Paul M J , Kapoor Nitin , Paul Thomas , Chacko Ari G , Thomas Nihal

Objective: We report the rare case of a 45-year-old male with multiple endocrine neoplasm 1 (MEN1) with simultaneous occurrence characteristic tumours leading to a delicately balanced metabolic homeostasis.Methods: Clinical, biochemical, and radiological data of this patient diagnosed to have MEN1 were analysed and the challenges in the management of these neuroendocrine tumours are discussed.Case illustration: A 45-year-old gentle...

ea0038p271 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evaluation of hypoglycaemia unawareness in individuals with type 1 diabetes mellitus using continuous glucose monitoring in a tertiary care centre

Naik Dukhabandhu , Shilpa R M , Mahesh D M , Asha H S , Kapoor Nitin , Paul Thomas , Padmanabhan V , Inbakumari Mercy , Christina Flory , Rani Jansi , Natarajan Divya , Jeyaseelan L , Thomas Nihal

Background: Intensive glycemic control forms the benchmark of management of type 1 diabetes mellitus (T1DM) and is limited by the risk of hypoglycaemia. Repeated episodes of hypoglycaemia can lead to development of hypoglycaemia unawareness and a sixfold increase in deaths in those experiencing severe hypoglycaemia. Severe hypoglycaemia occurs in 35–42% patients with T1DM. However, there is lack of data from our population and hence we aimed to objectively estimate the pr...