Endocrine Abstracts

Among well-known circulating melanoma markers 5-S-cysteinyldopa (5-SCD), a precursor of pheomelanin biosynthesis and S-100 beta (S-100B) are extensively investigated. Our earlier observations confirmed that serum concentration of 5-SCD and S-100B correlates well with the stages and progression of the disease. Interleukin-6 (IL-6) is a multifunctional inflammatory cytokine implicated in advanced stage of various diseases and tumour recurrence. Malignant melanoma cells are known...

Human breast cancer tissue is able to concentrate estrogens. 17-beta-estradiol (E2) and estrone (E1) are produced locally through several mechanisms, e.g. from conjugated and unconjugated steroid hormones uptaken from the circulation. This study was aimed to investigate the correlation between endogenous serum sex steroid concentrations and tumour receptor status in postmenopausal breast cancer patients undergoing surgical intervention. The study involved 740 postmenopausal pa...

The present study was undertaken to evaluate the diagnostic performance of a high-sensitive thyroglobulin (Tg) immunoradiometric assay (BRAHMS Tg-S) in the follow-up of papillary and follicular thyroid cancer patients treated with total/nearly total thyreoidectomy and radioiodine ablation therapy. During TSH suppression serum Tg concentration was measured 6 weeks prior to the radioiodine ablation (onT4-Tg before ablation) as well as 3 months following treatment (onT4–Tg a...