Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep86 | Adrenal and Cardiovascular Endocrinology | ECE2020

VDR-GR complex reduces apoptosis in acute myeloid leukemia cells via reduction of GR transcriptional activity

Karapanagioti Angeliki , Nasiri-Ansari Narjes , Kalotychou Vasiliki , Lembesis Panayiotis , Randeva Harpal , Papavassiliou Athanasios G , Kassi Evanthia

Introduction: Glucocroticoids (GCs) which are routinely used in the treatment of Acute Lymphocytic Leukemia (ALL), found recently to be beneficial in a subset of AML patients resistant to chemotherapy, by promoting leukemia cells apoptosis. Current studies indicate that vitamin D (VitD) deficiency is highly prevalent among AML patients, posing vitamin D as a therapeutic supplementation. Our previous study demonstrated that VitD exerts inhibitory effect on Dexamethasone-induced...

ea0056p673 | Nuclear receptors and Signal transduction | ECE2018

Vitamin D abolishes the dexamethasone-induced apoptosis in acute myeloid leukemia cells via regulation of Notch signaling

Karapanagioti Angeliki G , Nasiri-Ansari Narjes , Angelousi Anna , Kalotychou Vasiliki , Papavasilliou Athanasios G , Kassi Eva

Introduction: Glucocorticoids are used for treatment of various hematological malignancies such as Acute Myeloid Leukemia (AML). Glucocorticoids are known to induce apoptosis by regulating the expression of key anti- or pro-apoptotic genes. Vitamin D induces apoptosis and cell cycle arrest in various types of cancer cells. Despite recent advances in treatment of AML, the poor response rate to therapy remains a big challenge.Therefore, discovering new factors that can affect th...

ea0073yi7 | Young Investigator Awards | ECE2021

Alterations in clock genes expression in eutopic and ectopic endometrial tissue

Karapanagioti Angeliki , Narjes Nasiri-Ansari , Mavrogianni Despoina , Randeva Harpal , Papavassiliou Athanasios G. , Drakakis Peter , Kassi Evanthia

IntroductionEndometriosis is a dysplastic disease affecting approximately 7–10% of reproductive–aged women. It is defined as the presence of endometrial-like tissue outside the uterine cavity. Disruption of circadian rhythm in night shift worker has been associated with menstrual irregularity and increased chance of developing endometriosis and ovarian tumors. The central circadian clock system located in hypothalamic suprachiasmatic nucleus (...

ea0073aep555 | Pituitary and Neuroendocrinology | ECE2021

Abberant expression pattern of circadian clock genes in Type 1 gastric neuroendocrine neoplasms compared to ECL hyperplasia

Karapanagioti Angeliki , Daskalakis Kosmas , Nasiri-Ansari Narjes , Vlachou Erasmia , Kyriakopoulos Georgios , Kassi Evanthia , Kaltsas Gregory

PurposeThere is a continuity of changes ranging from enterochromaffin‐like (ECL) cell hyperplasia to type 1 gastric neuroendocrine neoplasms (GNEN1) with important clinical implications. Although the effect of the circadian clock system on tumorigenesis has been addressed, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 remains to be explored.MethodsSix patie...

ea0081p422 | Pituitary and Neuroendocrinology | ECE2022

Aberrant expression of clock genes in human gastric neuroendocrine tumors type 1

Karapanagioti Angeliki , Nasiri-Ansari Narjes , Daskalakis Kosmas , Vlachou Erasmia , Kyriakopoulos Georgios , Randeva Harpal , Kaltsas Gregory , Kassi Eva

Introduction: Gastric neuroendocrine tumors (GNET) are rare gastric neoplasms which are developed due to hypergastrinemia and enterochromaffin-like (ECL) cell hyperplasia. Although the effect of the circadian clock system disruption on tumorigenesis has been already studied in various malignancies and autoimmune diseases, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 (Type 1 Gastric Neuroendocrine Neoplasms) remains unexplored.</p...

ea0081ep937 | Reproductive and Developmental Endocrinology | ECE2022

Melatonin ameliorates glucocorticoid-induced invasiveness and circadian rhythm disruption in human endometrial adenocarcinoma cells

Karapanagioti Angeliki , Nasiri-Ansari Narjes , Kyrou Ioannis , Mavrogianni Despoina , Drakakis Peter , kaltsas gregory , Papavassiliou Athanasios G. , Randeva Harpal , Kassi Eva

Introduction: The biological rhythm pattern is synchronized through circadian oscillation of cortisol and melatonin release. Increased cortisol levels and circadian rhythm disruption act as an oncogenic factor in endometrial cancer through among others- dysregulation of cell proliferation/apoptosis and invasion.Aim: To investigate, whether there is an oscillatory expression of the clock genes, MT1 and GR expression in human endometrial carcinoma cells. T...

ea0063p1025 | Interdisciplinary Endocrinology 2 | ECE2019

In vitro study of Orexin alpha effects on factors involved in atherosclerosis: a dual role?

Karapanagioti Angeliki , Spenzta Flora , Dimitriadis Georgios K. , Nasiri-Ansari Narjes , Lianidou Evi , Papavassiliou Athanasios G , Randeva Harpal S , Kassi Eva

Introduction: Malnutrition in neonates and children has been associated with adult-onset diseases such as obesity and atherosclerosis. Infants breastfeeding exhibit a different pattern of orexin-α secretion compared to formula-fed or infants on parenteral feeding. Given the protective role of maternal milk in the onset of metabolic syndrome and atherosclerosis in later life, we hypothesized that orexin-α may be involved in this process. We studied in vitro t...

ea0056gp33 | Adrenal cortex | ECE2018

Alterations in Clock genes expression in human benign adrenal tumors

Angelousi Anna , Nasiri-Ansari Narjes , Karapanagioti Angeliki , Aggeli Chrysanthi , Zografos Georgios , Chrousos Georgios , Kaltsas Gregory , Kassi Eva

Introduction: Alteration in the expression of clock-related genes has been observed in various diseases. Adrenal sensitivity to adrenocorticotropic hormone (ACTH) apart from the hypothalamo-pituitary-adrenal axis is also regulated by the intrinsic adrenal clock. A link between clock genes and glucocorticoid adrenal production has been suggested by in vitro and animal studies. In the present study we investigated clock genes expression in human benign tumors of the adr...

ea0081rc5.4 | Rapid Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

Empagliflozin induces endocan expression and alleviates NAFLD through regulation of NF-κB pathway

Nasiri-Ansari Narjes , Kyriakopoulos Georgios , Kyrou Ioannis , Flessa Christina-Maria , Lianou Maria , Karapanagioti Angeliki , Kaltsas Gregory , Papavassiliou Athanasios G , Randeva Harpal S , Kassi Eva

Introduction: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disorders. Endocan is a novel molecule of endothelial dysfuction which is expressed in liver. SGLT2i have been reported to improve NAFLD through amelioration of inflammation. While there are contradictory results regarding the serum endocan levels in NAFLD patients, data regarding endocan expression in liver tissue are limited. Aim: Herein, we aimed to investigat...

ea0070oc6.3 | Hot Topics (including COVID-19 | ECE2020

Expression of estrogen-related receptors and epidermal growth factor receptor in normal adrenal cortex and adrenocortical tumors: A possible role of GPR30 and EGFR in adrenocortical malignancy

Parianos Christos , Kyriakopoulos Georgios , Nasiri-Ansari Narjes , Karapanagioti Angeliki , Angelousi Anna , Aggeli Chrysanthi , Zografos Giorgos , Choreftaki Theodosia , Kounadi Theodora , Randeva Harpal , Kaltsas Gregory , Papavassiliou Athanasios G , Kassi Evanthia

Introduction: The majority of adrenal neoplasms are benign while adrenocortical carcinomas (ACC) are rare with poor prognosis. Previous studies indicated that estrogens play important role in the etiology and progression of adrenocortical tumors. Estrogens exert genomic activities trough the estrogen-receptor (ER) subtypes α and β, while the non-genomic effects are mediated by membrane-bound-G-protein-coupled-ER-30 (GPR30). Although estrogens induce cancer cell ...