Searchable abstracts of presentations at key conferences in endocrinology

ea0032p641 | Male reproduction | ECE2013

Mortality is increased in men treated with testosterone compared to age and sex-matched controls

Karmisholt Jesper , Eriksen Stine , Rungby Jorgen , Vestergaard Peter

Background: Symptomatic hypogonadism is frequent and associated with increased risk of cardiovascular events. Hypogonadism is often treated with testosterone replacement. In a recent meta-analysis on adverse events in randomised placebo controlled testosterone replacement trials (RPCT), no differences between testosterone or placebo/non-intervention groups with regards to cardiovascular events or risk factors was observed. Conversely, a contemporary RPCT in elderly immobile pa...

ea0084ps1-05-38 | Miscellaneous | ETA2022

TSH is superior to T4 for the assessment of thyroid function

Andersen Stig , Linding Andersen Stine , Bruun Henrik , Riis Johannes , Noahsen Paneeraq , Westergaard Louise , Karmisholt Jesper

Background: Morbidity and mortality are associated with thyroid hormone levels in populations. This has invited a debate on what is the better parameter for assessment of thyroid function: the controlling hormone thyrotropin (TSH) or peripheral thyroid hormone measurements (thyroxine (T4) and triiodothyronine (T3)).Aim: To assess the ability of TSH and total T4 (TT4) to discriminate between subtle differences in thyroid function.Me...

ea0081p512 | Late-Breaking | ECE2022

Changes in acromegaly presentation and treatment over a three-decade period

Aagaard Charlotte , S Christophersen Amanda , Finnerup Susanne , Rosendal Christian , Vestergaard Peter , Karmisholt Jesper , H Nielsen Eigil , Dal Jakob

Objective: To study time-dependent changes in the prevalence and patient characteristics of acromegaly, as well as to access the impact of changes in treatment on disease control.Methods: A total of 107 patients with acromegaly were identified by healthcare registries and subsequently validated by patient chart review over a three-decade period (1992-2021).Results: The prevalence of acromegaly significantly increased throughout the...

ea0084op-06-31 | Oral Session 6: Hypothyroidism | ETA2022

Does subclinical hypothyroidism add on any symptoms? evidence from a danish population-based study

Carle Allan , Karmisholt Jesper , Knudsen Nils , Perrild Hans , Thuesen Betina , Ovesen Lars , B Rasmussen Lone , Bulow Pedersen Inge

Background: Few studies have scrutinized the spectrum of symptoms in subclinical hypothyroidism.Methods: From three DanThyr cross-sectional surveys performed in the period 1997 to 2005, a total of 8,903 volunteers participated in a comprehensive investigation including blood samples and questionnaires on previous diseases, smoking habits, alcohol intake, and education. From the three surveys we included patients with unknown subclinical hypothyroidism (<...

ea0090p405 | Pituitary and Neuroendocrinology | ECE2023

The TRH test is a valuable diagnostic test in central hypothyroidism with low T4

Norma Smith* Liv , Ellegaard Christensen* Sara , Rosendal Christian , Angela Gulisano Helga , Ettrup Kare , H Nielsen Eigil , Karmisholt Jesper , Dal Jakob

Objective: To evaluate the value of the thyrotropin-releasing hormone (TRH) test in the diagnosis of central hypothyroidism (CH) in patients with pituitary disease.Methods: Systematic evaluation of 368 TRH tests including measurements of TBG corrected thyroxine (T4corr), baseline TSH (TSH0) and fold and absolute TSH increase (TSHfold, TSHabsolute) in patients with pituitary disease.Result...

ea0092op-06-01 | Oral Session 6: Pregnancy | ETA2023

Antithyroid drug exposure during 1,191,904 pregnancies in denmark: a 20-year longitudinal study before and after implementation of iodine fortification

Maria Uldall Torp Nanna , Liew Zeyan , Carle Allan , Scott Karmisholt Jesper , Bulow Pedersen Inge , Andersen Stig , Linding Andersen Stine

Objectives: Hyperthyroidism in pregnant women is a clinical concern, and it is important to surveil any change in the occurrence of hyperthyroidism within the pregnant population specifically, especially when a mandatory iodine fortification (IF) program is implemented as it was in Denmark in the year 2000. This longitudinal study aimed to investigate any change in the use of antithyroid drugs (ATD) for the treatment of hyperthyroidism in Danish pregnant women during a 20-year...

ea0092ps3-23-01 | Pregnancy | ETA2023

TSH elevation before or after a pregnancy according to unidentified maternal thyroid function and thyroid autoantibody status in the early pregnancy: A study of 13,664 danish pregnant women

Linding Andersen Stine , Hjelm Lundgaard Maja , Maria Uldall Torp Nanna , Lykkeboe Simon , Carle Allan , Karmisholt Jesper , Bulow Pedersen Inge , Vestergaard Peter , Andersen Stig

Objectives: One of the risk-based screening criteria for thyroid disease in pregnancy is previous abnormal thyroid function or thyroid autoantibody-positivity. We speculated on the frequency and results of thyroid function testing in women of fertile age as part of routine care before and after a pregnancy.Methods: The North Denmark Region Pregnancy Cohort includes retrospective assessment of thyroid function and thyroid autoantibodies (ADVIA Centaur XPT...

ea0084op-05-23 | Oral Session 5: Autoimmunity | ETA2022

Cut-offs for thyroid peroxidase and thyroglobulin antibodies in early pregnancy are not similar and may differ from non-pregnant individuals: evidence from 10,905 danish pregnant women

Linding Andersen Stine , Henrik Bruun Niels , Astrup Christensen Peter , Lykkeboe Simon , Handberg Aase , Bo Hansen Annebirthe , Berg Hjelm Maja , Knosgaard Louise , Maria Uldall Torp Nanna , Carle Allan , Scott Karmisholt Jesper , Bulow Pedersen Inge , Vestergaard Peter , Andersen Stig

Objectives: Thyroid disease in women of reproductive age is predominantly of autoimmune origin, and thyroid peroxidase antibodies (TPO-Ab) as well as thyroglobulin antibodies (Tg-Ab) are key markers of autoimmune hypothyroidism. Adding to this, much focus in pregnancy is on euthyroid women who are positive for thyroid autoantibodies. The observational findings are diverse, and evidence to substantiate the applied cut-offs for definition of thyroid autoantibody-positivity in ea...