Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep319 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Vitamin D supplementation and glucose metabolism parameters in pre-diabetic women

Andreeva Alena , Karonova Tatiana

Objective: To assess glucose metabolism (GM) parameters before and after vitamin D treatment in pre-diabetic women.Material and Methods: In the study were included fifty eight women with prediabetes (impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)) aged from 40 to 55 with signed informed consent. The study didn’t include women with diseases affecting the vitamin D metabolism, as well as women receiving regular vitamin D supplemen...

ea0063gp122 | Diabetes: Late Complications | ECE2019

Vitamin D supplementation and dynamics of LDF skin microcirculation in patients with diabetes mellitus and diabetic polyneuropathy

Stepanova Anna , Karonova Tatiana , Galagoudza Mikhail , Jude Edvard

Hypothesis: High doses of vitamin D (VitD) improves dermal microcirculation (MC) in diabetic patients with type 2 diabetes mellitus (T2DM) and diabetic neuropathy (DN).Purpose: To study the effect of different VD doses on skin MC values in T2DM patients and DN.Materials and methods: Sixty-two non-smoking T2DM patients with DN were randomized into two groups: Group 1 received 5000 IU (G1) and Group 2 received 40000 IU (G2) of cholec...

ea0063p484 | Calcium and Bone 2 | ECE2019

Bone mineral density and 10-year probability of fractures in type 2 diabetic patients with different vitamin D status

Andreeva Alena , Burmistrova Daria , Grigorieva Alexandra , Bystrova Anna , Karonova Tatiana

Objective(s): Last data showed advantages of TBS assessment of bone quality over BMD in patients with type 2 diabetes (T2D). We perform DXA in patients with T2D and calculated 10-year probability of fracture using FRAX® tool.Material and methods: A total of 252 (172 females) T2D patients aged 36 to 86 y.o (mean 61.0±8.8) were examined. BMD was performed in 124 patients (110 females) using DXA (Lunar Prodigy, USA). BMD adjusted for TB...

ea0049ep200 | Neuroendocrinology | ECE2017

Insulinoma: diagnostic features and treatment management

Khacimova Liana , Karonova Tatiana , Tsoy Uliana , Ianevskaia Liubov , Grineva Elena

Backgraund: Insulinoma is the most common functional pancreatic neuroendocrine tumor originating from β-cells, with unregulated insulin production and rarely associated with MEN-I syndrome. Diagnosis and treatment of insulinoma are a challenge in the practice of endocrinologist.Aim: To determine on the basis of retrospective analysis the optimal approaches to the management of patients with organic hyperinsulinism.Materials an...

ea0070oc6.4 | Hot Topics (including COVID-19 | ECE2020

High-dose Vitamin D supplementation reduces inflammation and improves microcirculation in patients with diabetic peripheral neuropathy – a randomized control trial

Stepanova Anna , Karonova Tatiana , Bystrova Anna , Jude Edward

Background: In recent years, the role of vitamin D in improving the profile of inflammatory markers in order to prevent and treat diabetic neuropathy and microcirculation disorders has been actively studied.Aims: The research goal was to study the dynamics of inflammatory markers, clinical manifestations of diabetic peripheral neuropathy and laser Doppler flowmetry of skin microcirculation during treatment with various doses of cholecalciferol in patient...

ea0070ep109 | Bone and Calcium | ECE2020

Hip fracture and the brown tumors as clinical manifestation of primary hyperparathyroidism in late reproductive age woman: Case report.

Yanevskaya Liubov , Karonova Tatiana , Pogosian Karina , Ryzhkova Daria , Grineva Elena

Purpose: Primary hyperparathyroidism (PHPT) is the third common endocrine disorder which often manifest with skeletal or renal disfunction. In developed countries asymptomatic form is the most common and such severe manifestations as osteofibrosis cystica are very rare.Clinical case: We present the case of 49-years-75 × 66 old caucasian woman, with history of urolithiasis, nephrolithotripsy in 2014. In November 2016 she was diagnosed with left femur...

ea0056p291 | Calcium & Vitamin D metabolism | ECE2018

Vitamin D deficiency and risk of metabolic syndrome

Andreeva Alena , Belyaeva Olga , Bystrova Anna , Bajenova Elena , Karonova Tatiana

Objective: Recent studies suggest that vitamin D deficiency could be a risk factor for metabolic abnormalities.The aim of this study was to assess the relationship between 25(OH)D level and metabolic syndrome components.Materials and methods: A total of 697 women from 30 to 55 y.o. were examined. Exclusion criteria were, clinically significant endocrine, renal, liver and GI diseases, regular insolation and intake of vitamin D and c...

ea0081p509 | Late-Breaking | ECE2022

Neuroprotective properties of GLP-1 receptor agonists and SGLT-2 inhibitors in experimental stroke

Simanenkova Anna , Timkina Natalya , Karonova Tatiana , Tikhomirova Polina , Gagiev Alexandr , Radugin Fedor , Vlasov Timur

Background and aims: The most outstanding cardioprotective potential has been demonstrated for GLP-1 receptor agonists (GLP-1RA) and SGLT-2 inhibitors (SGLT-2i). But only long-acting GLP-1RA dulaglutide (DULA) and semaglutide decrease stroke incidence, while data concerning the influence of any drug on stroke severity are lack. At the same time, ischemic stroke remains one of the leading causes of death in type 2 diabetes mellitus (DM2). The aim of our study was to investigate...

ea0081ep134 | Calcium and Bone | ECE2022

«Hungry bone» syndrome in delay diagnosed primary hyperparathyroidism with fibrocystic osteitis: A case report

Pogosian Karina , Yanevskaya Lubov , Mikhailova Arina , Semenova Alisa , Ryzhkova Daria , Belousova Lidia , Tsoy Uliana , Karonova Tatiana

Background Fibrocystic osteitis is rare PHPT manifestation. Poor management and delay in diagnosis of fibrocystic osteitis may lead to reduced quality of life and also provoke severe postoperative hypocalcemia – «hungry bone» syndrome.Clinical case We present a case of 66-years-old Caucasian woman, with history of urulithiasis/nephrocalcinosis (CKD stage 4), two pathological fractures, and fibrocystic osteitis. In Jan 2021...

ea0081ep643 | Pituitary and Neuroendocrinology | ECE2022

Primary hyperparathyroidism response to the somatostatin analogue therapy in a patient with MEN1 syndrome: A case report

Yakovenko Kseniia , Pogosian Karina , Ryzhkova Daria , Belousova Lidiia , Karonova Tatiana , Grineva Elena , Tsoy Uliana

Background: Management of primary hyperparathyroidism (PHPT) in Multiple Endocrine Neoplasia type 1 syndrome (MEN 1) is still a challenge. PHPT developing in MEN 1 is characterized by the involvement of all parathyroid glands. Therefore, by modern guidelines, total or subtotal removal of the parathyroid glands is recommended. But this approach often leads to the development of hypoparathyroidism, adequate correction of which is not always possible. Drug therapy of recurrent PH...