Searchable abstracts of presentations at key conferences in endocrinology

ea0090p568 | Adrenal and Cardiovascular Endocrinology | ECE2023

Assessment of Practice around Corticosteroid Sick Day Rules in Transplant and Oncology Services of a Tertiary Hospital in UK

Naeem Ammara , Yousseif Ahmed , Khoo Bernard , Karra Efthimia , Armeni Eleni

Introduction: Long term treatment with corticosteroids has been widely used, due to the well documented immunosuppressive and anti-inflammatory activity. Corticosteroids are among the most widely prescribed drugs in oncology and post-transplant patients. However, long-term treatment with a dose of corticosteroids, which equals prednisolone 5mg/day for at least 4 weeks, is very likely to result in suppressed function of the hypothalamic pituitary adrenal (HPA) axis, a condition...

ea0065p52 | Adrenal and Cardiovascular | SFEBES2019

Inpatient pheo crisis in neurofibromatosis type1 (NF 1) ‘Triggers and management’

Eltayeb Randa , Khoo Bernard , Karra Efthimia , Bitat Syed , Ali Sarah

Pheochromocytoma crises are uncommon but have high mortality. We describe herein a case where multidisciplinary team management was crucial in safely carrying the patient through such a crisis. The patient was a 63 year old lady with a background of neurofibromatosis type 1 (NF-1), and previous renal artery stenosis bypass surgery. She was admitted via A&E with increasingly frequent episodes of sweating, headache, dyspnoea and palpitations. Her troponin was raised at admis...

ea0093p2 | Guided Poster Tour 1: Adrenal and Neuroendocrine tumors | EYES2023

Assessment of the hypothalamus–pituitary–adrenal axis in patients following adrenalectomy

Taylor Sabrina , Gao Hao , Shekhda Kalyan , Karra Efthimia , Armeni Eleni

Background: Resection of the adrenal gland is a challenging intervention that requires close endocrinological supervision for the correct assessment of hormones to minimise complications peri-operatively (peri-op) and post-operatively (post-op).Objectives: This study assessed the function of the hypothalamus–pituitary–adrenal axis and the related management according to underlying adrenal disorders.Methods: We reviewed 16...

ea0082wd10 | Workshop D: Disorders of the adrenal gland | SFEEU2022

Cushing”s crises arising from a neuroendocrine tumour treated with etomidate infusion

Islam Quazi , Eltayeb Randa , Eldigair Hiba , Khoo Bernard , Yousseif Ahmed , Karra Efthimia , Patel Dipesh

Introduction: Ectopic ACTH syndrome is rare but is frequently severe condition because of the intensity of the hypercortisolism that may be dissociated from the tumoral condition. It should often be considered as an endocrine emergency requiring an emergency response both in terms of diagnostic procedures and therapeutic interventions. Patient management is complex and necessitates dual skills, in the diagnosis and treatment (1). Etomidate, an imidazole-derivative anesthetic a...

ea0069p63 | Poster Presentations | SFENCC2020

Coexistence of Refetoff syndrome and papillary thyroid carcinoma

Aziz Umaira , Banu Zeenat , Eltayeb Randa , Eldigair Hiba , Yousseif Ahmed , Karra Efthimia

A 30 year-old Caucasian male presented for a routine check-up. He was known to have abnormal thyroid function tests since the age of 23 years of unclear nature/aetiology. He reported occasional palpitations and anxiety. There were no other symptoms on systems’ review. He did not take regular medication, was an ex-smoker and consumed alcohol socially. His mother had hypothyroidism and his maternal aunt’s thyroid nodules. He was euthyroid. A palpable isthmic nodule &#7...

ea0082p1 | Poster Presentations | SFEEU2022

Pseudohypoparathyroidism presenting with extensive bone lytic lesion histology proven Brown tumours

Eltayeb Randa , Sahoo Saroj , ISLAM Quazi , Eldigair Hiba , Armeni Eleni , Patel Dipesh , Karra Efthimia , Yousseif Ahmed , Khoo Bernard

Summary: 59-year-old female diagnosed at the age of 41 in 2004 with pseudohypoparathyroidism (PHP) initially presenting with raised PTH 152 pmol/l (1.6-6.9), Phosphate 1.91 mmol/l (0.87-1.45), adjusted calcium 1.90 mmol/l (2.20-2.60), raised ALP 600 units/l (0-129) and low vitamin D 29 nmol/l. Since diagnosis started on alfacalcidol 1 mg daily and Calcichew-D3. Investigations by hepatology team in the view of persistently raised ALP showed normal liver ultrasound, Fibroscan an...

ea0082p32 | Poster Presentations | SFEEU2022

Pituitary Apoplexy presenting with acute hyponatraemia

Islam Quazi , Sahoo Saroj , Naeem Ammara , Eldigair Hiba , Mehta Jay , Khoo Bernard , Karra Efthimia , Yousseif Ahmed , Patel Dipesh , Armeni Elena

Case history: 48-years old man, with no comorbidities, presented to A&E due to global headache of 20 days duration, with associated intermittent vomiting, but no photophobia, cranial nerve impairment, neck pain or visual disturbance. The first head-scan (CT, computed tomography) was unremarkable, hence was discharged with safety advises. One week later, he represented to A&E with similar complaints. On enquiries, he mentioned to be reviewed by an optician 6 months ago,...

ea0086p249 | Neuroendocrinology and Pituitary | SFEBES2022

Acute hypoglycemia as the presenting manifestation secondary to pituitary metastasis in a patient with malignant melanoma

Sahoo Saroj , Eltayeb Randa , Islam Quazi , Naeem Ammara , Patel Dipesh , Yousseif Ahmed , Armeni Eleni , Karra Efthimia , Khoo Bernard , Grossman Ashley

Introduction: Pituitary metastasis (PM) is a rare condition and associated with a reduced life-span. The most common primary sites are breast and lung, followed by thyroid and renal cell carcinoma. Patients with PM are mostly asymptomatic and incidentally discovered during neuroimaging. Characteristic symptoms are reported in <20% and most commonly include visual involvement, diabetes insipidus, and panhypopituitarism. We here describe a case with malignant melanoma (MM) w...

ea0069p68 | Poster Presentations | SFENCC2020

Refractory cyclical cushing’s – clinical challenges

Banu Zeenat , Eltayeb Randa , Aziz Umaira , Eldigair Hiba , Tickle Eliane , Khoo Bernard , Yousseif Ahmed , Al-barazi Sinan , Karra Efthimia

Case history: Cyclical Cushing’s is a very rare disease with rhythmic fluctuations in cortisol production with or without phenotypic features. It is a very challenging entity to diagnose. The low index of clinical suspicion is key for timely diagnosis and prevention of long-term complications. A 66 years old male presented with intermittent, episodic bilateral leg swelling and reversible weight gain of ˜6 kg following these episodes. Background history entailed femor...

ea0044oc5.4 | Diabetes Mellitus and Metabolism | SFEBES2016

Two contrasting cases of spontaneous severe hypoglycaemia secondary to anti-insulin antibodies (Insulin Autoimmune Syndrome / Hirata disease)

Moorthy Myuri , Freudenthal Bernard , Church David , Kisalu Judith , Woolman Emma , Hale Amy , Beynon Huw , Karra Efthimia , Cohen Mark , Khoo Bernard

IAS is a very rare condition in which anti-insulin antibodies carry high concentrations of insulin in suspension in circulation. Hypoglycaemia occurs when insulin is released from the antibodies during fasting or post-prandially.We present two cases. Patient-A is a 52-year old Thai obese female, with acanthosis nigricans and a strong family history of T2DM. Patient-B is a 28 year-old normal- BMI Caucasian female with an unremarkable history. None of the ...