Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep215 | Calcium and Bone | ECE2023

Short-term treatment with 2000IU of cholecalciferol in patients with secondary hyperparathyroidism due to vitamin d insufficiency

Angelopoulos Nikolaos , Boniakos Anastasios , Karras Spyridon , Paparodis Rodis , Livadas Sarantis

Introduction: Conventional treatment of secondary hyperparathyroidism (SHP) requires supplementation of vitamin d analogues combined with calcium however several studies have reported concerns regarding the safety of calcium supplements particularly in the long term. If vitamin d without concomitant calcium supplementation is sufficient to prompt a fall in the parathyroid hormone (PTH) is still not known with certainty. The purpose of our study was to investigate if vitamin d ...

ea0035p167 | Calcium and Vitamin D metabolism | ECE2014

Unusual case of intrathyroid parathyroid hyperplasia revealed by parathyroid hormone determination in fine-needle aspirate, co-existing with multifocal papillary thyroid carcinoma

Anagnostis Panagiotis , Karras Spyridon , Adamidou Fotini , Christoforidou Varvara , Cox Jeremy

Introduction: Ectopic parathyroid tissue is a rare cause of primary hyperparathyroidism (PHPT). Intrathyroid location has been reported in 18–33% of cases.Case report: A 67-year-old Caucasian female was admitted for evaluation of multi-nodular goiter and normocalcaemic PHPT. The patient was asymptomatic; her medical history was remarkable for hypertension, dyslipidaemia, and albuminuria. Her family history has positive for albuminuria.<p class="...

ea0081ep907 | Reproductive and Developmental Endocrinology | ECE2022

Associations of VDBP polymorphisms with birth neonatal anthropometry: a cohort study from Northern Greece

Karras Spyridon , Dursun Erdinc , Alaylioglu Merve , Ak Duygu Gezen , Pilz Stefan , Jude Edward , Anouti Fatme Al

Vitamin D binding protein (VDBP) has a critical role in orchestrating optimal vitamin D homeostasis and bioavailability. VDBP has been implicated in modulating the gene expression of amino-transporters within the placenta and might thus control the transfer of amino acids to neonates during in utero development. We hypothesize that dyshomeostasis of VDBP could lead to adverse metabolic profiles and low birth weight in neonates. VDBP genetic polymorphisms steer the uni...

ea0090p508 | Thyroid | ECE2023

The clinical significance of low dose biotin supplements (<300μg/day) in the treatment of patients with hypothyroidism: crucial or overestimated?

Angelopoulos Nikolaos , Paparodis Rodis , Androulakis Ioannis , Boniakos Anastasios , Karras Spyridon , Livadas Sarantis

Background: In the last decade, the combination of the widespread use of streptavidin-biotin technology and biotin–containing supplements (BCS) in the daily clinical practice, have led to numerous reports of erroneous hormone immunoassay results. However, there are no studies assessing the clinical and biochemical significance of that phenomenon, when treating patients with hypothyroidism. Therefore, a prospective study was designed to investigate the potential alteration...

ea0063gp204 | Diabetes: Pharmacotherapy | ECE2019

Fasting insulin levels correlate with the incidence of hypoglycemic events in patients with Type 2 Diabetes treated with sulfonylureas: a retrospective cross-sectional study

Kolokas Konstantinos , Koufakis Theocharis , Avramidis Iakovos , Gerou Spyridon , Chatzidimitriou Maria , Kazakos Kyriakos , Karras Spyridon , Kotsa Kalliopi

Background: Sulfonylureas (SUs) are known to increase fasting insulin levels in patients with Type 2 Diabetes (T2D) treated with these agents. Whether this increase is related to a greater risk of hypoglycemia has not yet been sufficiently elucidated.Methods: The study included 58 patients with T2D who had been on treatment with SUs, but not insulin, for more than 2 years. Confirmed hypoglycemic episodes during the past year were self-reported by the pat...

ea0041ep296 | Clinical case reports - Pituitary/Adrenal | ECE2016

Functional gonadotrophin axis evident as spontaneous puberty in a pediatric patient with hypopituitarism after caniopharyngioma resection: a case report

Rapti Eleni , Grammatiki Maria , Mousiolis Athanasios , Tsekmekidou Xanthippi , Resta Maria , Karras Spyridon , Yavropoulou Maria , Kotsa Kaliopi

Objective: To report a case of hypogonadism reversal and spontaneous puberty in a craniopharyngioma patient who suffered from hypopituitarism as a result of complete surgical resection.Methods: A 13-year-old boy with hypopituitarism was evaluated for right testicular sensitivity.At the age of 6 the child presented with growth arrest and a craniopharyngioma causing pituitary insufficiency was diagnosed. Treatment with hydrocortisnon...

ea0056p226 | Calcium &amp; Vitamin D metabolism | ECE2018

Glucose metabolism in primary hyperparathyroidism: The role of parathyroidectomy

Antonopoulou Vasiliki , Grammatiki Maria , Rapti Eleni , Koufakis Theocharis , Karras Spyridon , Yavropoulou Maria , Papavramidis Theodossis , Kotsa Kalliopi

Background: Although primary hyperparathyroidism (PHPT) has been associated with diabetes mellitus (DM), the etiological link is not clear and the effect of parathyroidectomy is controversial.The aim of this observational study was to investigate the metabolic link between calciotropic hormones and glucose metabolism in PHPT patients before and after parathyroidectomy.Methods: Twenty-four consecutive patients with PHPT (Group-A) without DM were included ...

ea0073aep804 | Late Breaking | ECE2021

Effects of Christian Orthodox versus intermittent fasting on plasma irisin concentrations in overweight adults

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Dimakopoulos Georgios , Karalazou Paraskevi , Thisiadou Katerina , Makedou Kali , Kotsa Kalliopi

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

ea0090ep134 | Calcium and Bone | ECE2023

Variations in plasma free 25-hydroxyvitamin D concentrations during intermittent fasting are independently correlated with amino acid intake among meat and non-meat eaters

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Dimakopoulos George , Melidou Eirini , Karalazou Paraskevi , Thisiadou Katerina , Zebekakis Pantelis , Makedou Kali , Kotsa Kalliopi

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

ea0063p192 | Diabetes, Obesity and Metabolism 1 | ECE2019

Large phenotypic variability of diabetes due to ABCC8 gene mutation illustrated by the paradigm of a family

Koufakis Theocharis , Sertedaki Amalia , Tatsi Elizabeth-Barbara , Trakatelli Christina-Maria , Karras Spyridon , Kanaka-Gantenbein Christina , Kotsa Kalliopi

Background: Monogenic Diabetes is relatively rare, representing only 1–2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as Type 1 Diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members.Methods: Case report.Results: We describe a case of a young patient who presented with hyperglycemia in the absence of ketosis and following genetic testing, he proved to h...