Searchable abstracts of presentations at key conferences in endocrinology

ea0029s36.3 | Bone and metabolism | ICEECE2012

Functions and mode of action of osteocalcin

Karsenty G.

We have proposed twelve years ago that bone mass accrual, energy metabolism and reproduction must be coordinately regulated by hormones that would appear during evolution with bone. This hypothesis has been tested and verified in several ways one of them being to show that osteocalcin, the most osteoblast-specific secreted protein, is a hormone that regulates insulin secretion, glucose homeostasis, energy expenditure and male fertility. The metabolic function of osteocalcin ha...