Endocrine Abstracts

Background: Numerous animal models have shown impressive beneficial metabolic effects of the putative thyroid hormone (TH)-derivative 3,5-diiodothyronine (3,5-T2), including the prevention of insulin resistance or the reversal of hepatic steatosis, in the absence of thyrotoxic side effects. In contrast, the endogenous fate of 3,5-T2 in humans is still unclear. Comprehensive molecular profiling holds promise to gain deeper insights in metabolic alterations associated with serum...